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    Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100270678, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spns2provided by RGD
    Official Full Name
    SPNS lysolipid transporter 2, sphingosine-1-phosphateprovided by RGD
    Primary source
    RGD:2303312
    See related
    EnsemblRapid:ENSRNOG00000057040 AllianceGenome:RGD:2303312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sphingolipid transporter activity and transmembrane transporter activity. Predicted to be involved in several processes, including regulation of T cell migration; sensory perception of sound; and sphingosine-1-phosphate receptor signaling pathway. Predicted to act upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and regulation of eye pigmentation. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 204.5), Kidney (RPKM 130.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spns2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57565909..57604546, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57067348..57105969, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59010428..59049482, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MYB binding protein 1a Neighboring gene gamma-glutamyl transferase 6 Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate Neighboring gene uncharacterized LOC134480821 Neighboring gene ubiquitin-conjugating enzyme E2G 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis. Vanderhaeghen T, et al. EMBO Rep, 2023 Aug 3. PMID 37358010, Free PMC Article
    2. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. Fukuhara S, et al. J Clin Invest, 2012 Apr. PMID 22406534, Free PMC Article
    3. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. Nijnik A, et al. J Immunol, 2012 Jul 1. PMID 22664872, Free PMC Article
    4. Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. Nagahashi M, et al. FASEB J, 2013 Mar. PMID 23180825, Free PMC Article
    5. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. Hisano Y, et al. J Biol Chem, 2011 Jan 21. PMID 21084291, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
      Title: Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sphingolipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingolipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymph node development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of eye pigmentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of humoral immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of humoral immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine-1-phosphate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine-1-phosphate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine-1-phosphate transporter SPNS2
    Names
    protein spinster homolog 2
    sphingolipid transporter 2
    spinster homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389255.1 → NP_001376184.1  sphingosine-1-phosphate transporter SPNS2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGF8, A6HGG0
      Related
      ENSRNOP00000068809.2, ENSRNOT00000078272.3
      Conserved Domains (1) summary
      cd17328
      Location:106 → 520
      MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      57565909..57604546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010055110.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144991.1: Suppressed sequence

      Description
      NM_001144991.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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