Nsun2 NOP2/Sun RNA methyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nsun2provided by RGD
Official Full Name: NOP2/Sun RNA methyltransferase 2provided by RGD
Primary source: RGD:1311954
See related: EnsemblRapid:ENSRNOG00000017254 AllianceGenome:RGD:1311954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311954
Summary: Predicted to enable mRNA (cytidine-5-)-methyltransferase activity; tRNA (cytidine-5-)-methyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including RNA processing; regulation of mRNA export from nucleus; and tRNA stabilization. Predicted to act upstream of or within hair follicle maturation and in utero embryonic development. Predicted to be located in several cellular components, including chromatoid body; extracellular exosome; and nucleolus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 162.8), Spleen (RPKM 160.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (35490583..35514839, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (33662139..33685887, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (36295650..36319906, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, NSun2 mediates HHcy-induced upregulation of IL-17A expression by methylating IL-17A mRNA and promoting its translation in T lymphocytes.
Title: Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes.
Nsun2 up-regulates the expression of ICAM-1 in vascular endothelium by methylation of ICAM-1 mRNA.
Title: NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463178 (e-PCR)
- UniSTS:208955

RH143267 (e-PCR)
- UniSTS:232514

RH132204 (e-PCR)
- UniSTS:215487

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (cytidine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hair follicle maturation	ISO Inferred from Sequence Orthology more info
involved_in hair follicle maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA processing	ISO Inferred from Sequence Orthology more info
involved_in tRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatoid body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA cytosine C(5)-methyltransferase NSUN2

Names: NOL1/NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family, member 2; NOP2/Sun domain family, member 2; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2

NP_001101873.1

EC 1.3.99.5

EC 2.1.1.29

XP_006227854.1

EC 1.3.99.5

EC 2.1.1.29

XP_063122019.1

EC 1.3.99.5

EC 2.1.1.29

XP_063122020.1

EC 1.3.99.5

EC 2.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108403.1 → NP_001101873.1 RNA cytosine C(5)-methyltransferase NSUN2

See identical proteins and their annotated locations for NP_001101873.1

Status: PROVISIONAL

Source sequence(s)

CH474002

UniProtKB/TrEMBL

A0A0G2JUK0, A6JV18, D4A3S8

Related

ENSRNOP00000023641.5, ENSRNOT00000023641.8

Conserved Domains (2) summary

TIGR00446
Location:103 → 454

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl17173
Location:194 → 452

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

35490583..35514839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265950.1 → XP_063122020.1 RNA cytosine C(5)-methyltransferase NSUN2 isoform X1

UniProtKB/TrEMBL

A6JV18, D4A3S8
XM_063265949.1 → XP_063122019.1 RNA cytosine C(5)-methyltransferase NSUN2 isoform X1

UniProtKB/TrEMBL

A6JV18, D4A3S8
XM_006227792.5 → XP_006227854.1 RNA cytosine C(5)-methyltransferase NSUN2 isoform X2

UniProtKB/TrEMBL

A0A0G2JUK0

Related

ENSRNOP00000101574.1, ENSRNOT00000161739.1

Conserved Domains (2) summary

TIGR00446
Location:103 → 430

nop2p; NOL1/NOP2/sun family putative RNA methylase

cl17173
Location:177 → 428

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...