Lpin2 lipin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpin2provided by MGI
Official Full Name: lipin 2provided by MGI
Primary source: MGI:MGI:1891341
See related: Ensembl:ENSMUSG00000024052 AllianceGenome:MGI:1891341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610511G02Rik
Summary: Enables phosphatidate phosphatase activity and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and triglyceride biosynthetic process. Located in cytosol and endoplasmic reticulum membrane. Is expressed in central nervous system; gonad; liver; lung; and retina. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 8.0), liver E18 (RPKM 7.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.3; 17 41.87 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (71490527..71556813)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (71183532..71249818)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation.
Title: Lipin2 ameliorates diabetic encephalopathy via suppressing JNK/ERK-mediated NLRP3 inflammasome overactivation.
Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
Title: Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
Title: Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis.
Title: Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.
Suppression of lipin 1 and lipin2 are the primary mechanism of increased phosphatidic acid levels in the liver during acetaminophen-induced liver injury and recovery.
Title: Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond but the phosphorylation of lipin 2 is not induced by insulin signaling.
Title: Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.
in addition to their roles during early adipogenesis, lipin1 and lipin2 also have a role in lipid droplet biogenesis.
Title: Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
Title: Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages
Title: Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
Data show that in the high-Chol diet apoE-KO mice, the mRNA and protein expression of lipin-1 and lipin-2 was markedly decreased.
Title: Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lpin2 (e-PCR), detects polymorphism
- UniSTS:206986

AI481352 (e-PCR)
- UniSTS:160691

AW742896 (e-PCR)
- UniSTS:209336

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidate phosphatase LPIN2

NP_001158357.1

EC 3.1.3.4

NP_001344720.1

EC 3.1.3.4

NP_075020.2

EC 3.1.3.4

XP_006524849.1

EC 3.1.3.4

XP_006524851.1

EC 3.1.3.4

XP_030105837.1

EC 3.1.3.4

XP_030105838.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164885.1 → NP_001158357.1 phosphatidate phosphatase LPIN2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC126942, AC154218, AW489885

Consensus CDS

CCDS50177.1

UniProtKB/TrEMBL

E9PWN0

Related

ENSMUSP00000118610.2, ENSMUST00000126681.8

Conserved Domains (3) summary

pfam04571
Location:39 → 144

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:672 → 897

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:504 → 594

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_001357791.1 → NP_001344720.1 phosphatidate phosphatase LPIN2 isoform 2

Status: VALIDATED

Source sequence(s)

AC126942, AC154218, AW489885

Consensus CDS

CCDS28956.1

UniProtKB/Swiss-Prot

Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5

Conserved Domains (3) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:634 → 859

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:466 → 556

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
NM_022882.4 → NP_075020.2 phosphatidate phosphatase LPIN2 isoform 2

See identical proteins and their annotated locations for NP_075020.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC126942, AC154218, AW489885

Consensus CDS

CCDS28956.1

UniProtKB/Swiss-Prot

Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5

Related

ENSMUSP00000119282.2, ENSMUST00000129635.8

Conserved Domains (3) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:634 → 859

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:466 → 556

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

71490527..71556813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249977.1 → XP_030105837.1 phosphatidate phosphatase LPIN2 isoform X3

Conserved Domains (3) summary

pfam04571
Location:1 → 64

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:602 → 827

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:434 → 524

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_030249978.2 → XP_030105838.1 phosphatidate phosphatase LPIN2 isoform X4

Conserved Domains (2) summary

pfam08235
Location:373 → 598

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:205 → 295

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006524786.4 → XP_006524849.1 phosphatidate phosphatase LPIN2 isoform X1

Conserved Domains (3) summary

pfam04571
Location:39 → 102

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:640 → 865

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:472 → 562

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
XM_006524788.4 → XP_006524851.1 phosphatidate phosphatase LPIN2 isoform X2

See identical proteins and their annotated locations for XP_006524851.1

UniProtKB/Swiss-Prot

Q8C357, Q8C7I8, Q8CC85, Q8CHR7, Q99PI5

Conserved Domains (3) summary

pfam04571
Location:1 → 106

Lipin_N; lipin, N-terminal conserved region

pfam08235
Location:634 → 859

LNS2; LNS2 (Lipin/Ned1/Smp2)

pfam16876
Location:466 → 556

Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain