Stt3a STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stt3aprovided by MGI
Official Full Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:105124
See related: Ensembl:ENSMUSG00000032116 AllianceGenome:MGI:105124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B5; Itm1
Summary: Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in co-translational protein modification; post-translational protein modification; and protein N-linked glycosylation via asparagine. Located in membrane. Is expressed in several structures, including craniocervical region bone and thoracic segment skeleton. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 52.7), genital fat pad adult (RPKM 23.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.67 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (36640640..36678918, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (36729344..36767622, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAT4 overexpression promotes antitumor immunity by regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer.
Title: FAT4 overexpression promotes antitumor immunity by regulating the β-catenin/STT3/PD-L1 axis in cervical cancer.
N-glycosyltransferases STT3A and STT3B isoforms are sufficient and required for effective PD-L1 protein induction in the general cell population of mesenchymal-like cancer cells.
Title: STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
results show that most of the STT3 TMDs are well inserted into the ER membrane on their own or in the presence of the natural flanking residues.
Title: Refined topology model of the STT3/Stt3 protein subunit of the oligosaccharyltransferase complex.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236091

RH124793 (e-PCR)
- UniSTS:161615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISO Inferred from Sequence Orthology more info
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in co-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in co-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-translational protein modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation via asparagine	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation via asparagine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
part_of oligosaccharyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of oligosaccharyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of oligosaccharyltransferase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Names: integral membrane protein 1; oligosaccharyl transferase subunit STT3A

NP_032434.3

EC 2.4.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.