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    Bgn biglycan [ Mus musculus (house mouse) ]

    Gene ID: 12111, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bgnprovided by MGI
    Official Full Name
    biglycanprovided by MGI
    Primary source
    MGI:MGI:88158
    See related
    Ensembl:ENSMUSG00000031375 AllianceGenome:MGI:88158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BG; PGI; DSPG1; PG-S1; SLRR1A
    Summary
    This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in bladder adult (RPKM 238.1), lung adult (RPKM 231.1) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bgn in Genome Data Viewer
    Location:
    X A7.3; X 37.33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72527207..72539542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73483601..73495936)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene ATPase, Ca++ transporting, plasma membrane 3 Neighboring gene cyclin Q, pseudogene 1 Neighboring gene predicted gene, 46680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Bischof AG, et al. Integr Biol (Camb), 2013 Aug. PMID 23817524
    2. Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cells. Chen XD, et al. J Bone Miner Res, 2002 Feb. PMID 11811564
    3. Biological interplay between proteoglycans and their innate immune receptors in inflammation. Frey H, et al. FEBS J, 2013 May. PMID 23350913, Free PMC Article
    4. Biglycan gene connects metabolic dysfunction with brain disorder. Ying Z, et al. Biochim Biophys Acta Mol Basis Dis, 2018 Dec. PMID 30291886, Free PMC Article
    5. Lack of biglycan reduces contact hypersensitivity in mice. Esser PR, et al. Contact Dermatitis, 2018 Nov. PMID 30039623

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
      Title: Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
    2. Dermal papilla cell-secreted biglycan regulates hair follicle phase transit and regeneration by activating Wnt/beta-catenin.
      Title: Dermal papilla cell-secreted biglycan regulates hair follicle phase transit and regeneration by activating Wnt/β-catenin.
    3. Investigating the temporal roles of decorin and biglycan in tendon healing.
      Title: Investigating the temporal roles of decorin and biglycan in tendon healing.
    4. Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype.
      Title: Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype.
    5. Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
      Title: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
    6. Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birthdagger.
      Title: Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.
    7. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix.
      Title: Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix.
    8. OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
      Title: OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
    9. Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
      Title: Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
    10. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
      Title: Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
    Submit: New GeneRIF Correction See all GeneRIFs (67)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within articular cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    biglycan
    Names
    bone/cartilage proteoglycan I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411776.1 → NP_001398705.1  biglycan isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL732461

    2. NM_007542.5 → NP_031568.2  biglycan isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_031568.2

      Status: REVIEWED

      Source sequence(s)
      AK164867, AL732461
      Consensus CDS
      CCDS30204.1
      UniProtKB/Swiss-Prot
      P28653, Q61355
      UniProtKB/TrEMBL
      Q3TNY9, Q3UXK8
      Related
      ENSMUSP00000033741.8, ENSMUST00000033741.15
      Conserved Domains (4) summary
      smart00013
      Location:63 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:96 → 323
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:72 → 92
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:94 → 151
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72527207..72539542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28653.1 GenPept UniProtKB/Swiss-Prot:P28653

    Gene LinkOut

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