Fezf2 Fez family zinc finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fezf2provided by MGI
Official Full Name: Fez family zinc finger 2provided by MGI
Primary source: MGI:MGI:1859823
See related: Ensembl:ENSMUSG00000021743 AllianceGenome:MGI:1859823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fez; Fezl; Zfp312
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell dedifferentiation; positive regulation of DNA-templated transcription; and regulation of neurogenesis. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future prosencephalon; retina; thymus; and vomeronasal organ. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 17.8), whole brain E14.5 (RPKM 14.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 6.36 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (10121561..10130771)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (12338992..12346803, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.
Title: Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities.
Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?
Title: Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?
Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.
Title: Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.
Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.
Title: Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells.
Genetically identified amygdala-striatal circuits for valence-specific behaviors.
Title: Genetically identified amygdala-striatal circuits for valence-specific behaviors.
Taken together, our results show that Fezf2 is indispensable in differentiation of bipolar precursors into cone OFF bipolar cells and in functional maturation of cone ON bipolar cells during development of mouse retina.
Title: Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina.
findings indicate a wider role for Fezf2 within gene expression networks that underpin the diversity of layer 5 cortical projection neurons.
Title: Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.
transient expression ofFezf2in the retina modulates the transcription ofBrn3band the survival of RGCs.
Title: Transient Expression of Fez Family Zinc Finger 2 Protein Regulates the Brn3b Gene in Developing Retinal Ganglion Cells.
Study shows that the transcription factor Fezf2 directly regulates various tissue-restricted antigens genes in medullary thymic epithelial cells independently of Aire. Mice lacking Fezf2 in mTECs displayed severe autoimmune symptoms, including the production of autoantibodies and inflammatory cell infiltration targeted to peripheral organs.
Title: Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Satb2 and Fezf2 regulation promotes subcerebral projection neuron identity in the developing cerebral cortex
Title: Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

General gene information

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Markers

MARC_15281-15282:1013612096:1 (e-PCR)
- UniSTS:267800

GDB:1318551 (e-PCR)
- UniSTS:18236

AI451466 (e-PCR)
- UniSTS:160356

Fezf2 (e-PCR), detects polymorphism
- UniSTS:530687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of GABAergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within telencephalon development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in telencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fez family zinc finger protein 2

Names: forebrain embryonic zinc finger; forebrain embryonic zinc finger-like protein 2; zinc finger protein 312

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080433.3 → NP_536681.2 fez family zinc finger protein 2

See identical proteins and their annotated locations for NP_536681.2

Status: VALIDATED

Source sequence(s)

AI325906, AK019996, BM963196, BU703203

Consensus CDS

CCDS26818.1

UniProtKB/Swiss-Prot

Q9D298, Q9ESP5

Related

ENSMUSP00000022262.5, ENSMUST00000022262.6

Conserved Domains (4) summary

COG5048
Location:284 → 390

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:380 → 436

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:274 → 294

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 339

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

10121561..10130771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247890.2 → XP_030103750.1 fez family zinc finger protein 2 isoform X1

UniProtKB/Swiss-Prot

Q9D298, Q9ESP5

Conserved Domains (4) summary

COG5048
Location:284 → 390

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:380 → 436

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:274 → 294

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 339

zf-H2C2_2; Zinc-finger double domain
XM_036158763.1 → XP_036014656.1 fez family zinc finger protein 2 isoform X1

UniProtKB/Swiss-Prot

Q9D298, Q9ESP5

Related

ENSMUSP00000153090.2, ENSMUST00000224714.2

Conserved Domains (4) summary

COG5048
Location:284 → 390

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:380 → 436

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:274 → 294

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 339

zf-H2C2_2; Zinc-finger double domain