Hdgf heparin binding growth factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdgfprovided by MGI
Official Full Name: heparin binding growth factorprovided by MGI
Primary source: MGI:MGI:1194494
See related: Ensembl:ENSMUSG00000004897 AllianceGenome:MGI:1194494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D3Ertd299e
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cytoskeletal protein binding activity; and growth factor activity. Acts upstream of or within cellular response to interleukin-7 and negative regulation of neuron apoptotic process. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; sensory organ; and telencephalon ventricular layer. Orthologous to human HDGF (heparin binding growth factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 92.7), CNS E11.5 (RPKM 90.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87813844..87823439)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87906090..87916132)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDGF stimulates liver tumorigenesis by enhancing reactive oxygen species generation in mitochondria.
Title: HDGF stimulates liver tumorigenesis by enhancing reactive oxygen species generation in mitochondria.
RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming.
Title: RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming.
liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities
Title: Hepatocarcinoma cell-derived hepatoma-derived growth factor (HDGF) induces regulatory T cells.
Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma.
Title: Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma [corrected].
HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue.
Title: Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation.
HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes
Title: Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration.
HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway.
Title: Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis.
HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP.
Title: Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein.
The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice.
Title: Hepatoma-derived growth factor (HDGF) is dispensable for normal mouse development.
we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action.
Title: Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI118077 (e-PCR)
- UniSTS:165259

D3Ertd299e (e-PCR), detects polymorphism
- UniSTS:167354

Hdgf (e-PCR), detects polymorphism
- UniSTS:495837

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatoma-derived growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331051.2 → NP_001317980.1 hepatoma-derived growth factor isoform 2

Status: VALIDATED

Source sequence(s)

AC158233
NM_001331052.2 → NP_001317981.1 hepatoma-derived growth factor isoform 3

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/TrEMBL

E0CXA0

Related

ENSMUSP00000124803.2, ENSMUST00000159492.8

Conserved Domains (1) summary

cl02554
Location:7 → 60

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
NM_001410032.1 → NP_001396961.1 hepatoma-derived growth factor isoform 4

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410033.1 → NP_001396962.1 hepatoma-derived growth factor isoform 5

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410034.1 → NP_001396963.1 hepatoma-derived growth factor isoform 6

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410035.1 → NP_001396964.1 hepatoma-derived growth factor isoform 2

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410036.1 → NP_001396965.1 hepatoma-derived growth factor isoform 2

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410037.1 → NP_001396966.1 hepatoma-derived growth factor isoform 2

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410038.1 → NP_001396967.1 hepatoma-derived growth factor isoform 3

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410039.1 → NP_001396968.1 hepatoma-derived growth factor isoform 3

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410040.1 → NP_001396969.1 hepatoma-derived growth factor isoform 3

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410041.1 → NP_001396970.1 hepatoma-derived growth factor isoform 7

Status: VALIDATED

Source sequence(s)

AC158233
NM_001410042.1 → NP_001396971.1 hepatoma-derived growth factor isoform 8

Status: VALIDATED

Source sequence(s)

AC158233
NM_008231.5 → NP_032257.3 hepatoma-derived growth factor isoform 1

See identical proteins and their annotated locations for NP_032257.3

Status: VALIDATED

Source sequence(s)

AC158233

Consensus CDS

CCDS17457.1

UniProtKB/Swiss-Prot

P51859, Q8BPG7, Q9CYA4, Q9JK87

UniProtKB/TrEMBL

E0CXA0

Related

ENSMUSP00000005017.9, ENSMUST00000005017.15

Conserved Domains (1) summary

cd05834
Location:8 → 92

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...