Wnt10b wingless-type MMTV integration site family, member 10B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt10bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 10Bprovided by MGI
Primary source: MGI:MGI:108061
See related: Ensembl:ENSMUSG00000022996 AllianceGenome:MGI:108061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt12
Summary: Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; jaw; nervous system; and surface ectoderm. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 34.8), lung adult (RPKM 7.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98668593..98676093, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98770712..98778206, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition.
Title: Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition.
Wnt10b regulates osteogenesis of adipose-derived stem cells through Wnt/beta-catenin signalling pathway in osteoporosis.
Title: Wnt10b regulates osteogenesis of adipose-derived stem cells through Wnt/β-catenin signalling pathway in osteoporosis.
Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice.
Title: Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice.
Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.
Title: Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.
BMP9 may upregulate Wnt10b via the COX-2/phospho-CREB-dependent manner.
Title: CREB/Wnt10b mediates the effect of COX-2 on promoting BMP9-induced osteogenic differentiation via reducing adipogenic differentiation in mesenchymal stem cells.
BMP6 and Wnt10b are major inhibitors and activators respectively and their balance regulates the telogen-anagen transition of hair follicles.
Title: The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles.
Treatment of secondary hyperparathyroidism with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level.
Title: Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion.
Wnt10b recruitment to lipid rafts and mTOR activation promotes regeneration of injured optic nerve.
Title: Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.
We examined a new culture condition for DPCs including addition of Wnt-10b, which promoted proliferation and maintained their HF induction ability for more than ten passages. These results suggest that Wnt-10b plays a pivotal role in proliferation and maintenance of DPCs in vitro
Title: Maintenance of Dermal Papilla Cells by Wnt-10b In Vitro.
Wnt10b expression was assessed by flow cytometry under estrogen- and TNFalpha-deficient conditions.
Title: Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt10b (e-PCR), detects polymorphism
- UniSTS:465415

Wnt10b (e-PCR), detects polymorphism
- UniSTS:526097

U30464 (e-PCR)
- UniSTS:125716

Wnt10b (e-PCR), detects polymorphism
- UniSTS:527132

Wnt10b (e-PCR), detects polymorphism
- UniSTS:471853

Wnt10b (e-PCR), detects polymorphism
- UniSTS:265270

AF029307 (e-PCR)
- UniSTS:180830

NoName (e-PCR)
- UniSTS:485019

Wnt10b (e-PCR), detects polymorphism
- UniSTS:507313

U30464 (e-PCR)
- UniSTS:186042

Wnt10b (e-PCR), detects polymorphism
- UniSTS:276942

Wnt10b (e-PCR), detects polymorphism
- UniSTS:508408

Wnt10b (e-PCR), detects polymorphism
- UniSTS:508409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of anagen	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to parathyroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fungiform papilla development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of timing of anagen	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-10b

Names: wingless related MMTV integration site 10b; wnt-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011718.2 → NP_035848.1 protein Wnt-10b precursor

See identical proteins and their annotated locations for NP_035848.1

Status: VALIDATED

Source sequence(s)

BC114969, U30464, U61970

Consensus CDS

CCDS27806.1

UniProtKB/Swiss-Prot

P48614, P70702

Related

ENSMUSP00000023732.6, ENSMUST00000023732.12

Conserved Domains (1) summary

cd19356
Location:45 → 389

Wnt_Wnt10b; Wnt domain found in protein Wnt-10b and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

98668593..98676093 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520892.5 → XP_006520955.1 protein Wnt-10b isoform X2

See identical proteins and their annotated locations for XP_006520955.1

UniProtKB/Swiss-Prot

P48614

Related

ENSMUSP00000154513.2, ENSMUST00000226846.2

Conserved Domains (1) summary

cl38924
Location:45 → 293

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
XM_006520891.4 → XP_006520954.1 protein Wnt-10b isoform X1

See identical proteins and their annotated locations for XP_006520954.1

UniProtKB/Swiss-Prot

P48614, P70702

Conserved Domains (1) summary

cd19356
Location:45 → 389

Wnt_Wnt10b; Wnt domain found in protein Wnt-10b and similar proteins
XM_006520893.2 → XP_006520956.1 protein Wnt-10b isoform X3

Conserved Domains (1) summary

cl38924
Location:1 → 267

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family