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    Ubl5 ubiquitin-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 66177, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ubl5provided by MGI
    Official Full Name
    ubiquitin-like 5provided by MGI
    Primary source
    MGI:MGI:1913427
    See related
    Ensembl:ENSMUSG00000084786 AllianceGenome:MGI:1913427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubl5a; beacon; 1110030M22Rik
    Summary
    Predicted to enable protein tag activity. Predicted to be involved in mRNA splicing, via spliceosome and protein modification process. Predicted to be active in cytoplasm and nucleus. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human UBL5 (ubiquitin like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 32.6), thymus adult (RPKM 28.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubl5 in Genome Data Viewer
    Location:
    9 A3; 9 7.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20554013..20558436)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20642717..20647140)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death. Wang W, et al. J Biol Chem, 2023 Jul. PMID 37315790, Free PMC Article
    2. Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5. Hatanaka K, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17026961
    3. Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse. Brailoiu GC, et al. Brain Res, 2003 Sep 12. PMID 12932856
    4. Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes†. Tscherner AK, et al. Biol Reprod, 2023 Nov 15. PMID 37669129, Free PMC Article
    5. Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Zou J, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29632206, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
      Title: Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
    2. This report is the first to describe changes in the intracellular and subcellular localization of UBL5 in response to hypo-osmotic conditions.
      Title: Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5.
    3. findings report of the presence and distribution of ubiquitin-like 5 in the mouse hypothalamus and pituitary
      Title: Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310746.2 → NP_001297675.1  ubiquitin-like protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC164565
      Consensus CDS
      CCDS80963.1
      UniProtKB/TrEMBL
      E0CZB3
      Related
      ENSMUSP00000125540.2, ENSMUST00000161882.8
      Conserved Domains (1) summary
      cd01791
      Location:1 → 111
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

    2. NM_001361025.1 → NP_001347954.1  ubiquitin-like protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164565
      Consensus CDS
      CCDS52733.1
      UniProtKB/Swiss-Prot
      Q9EPV8
      Related
      ENSMUSP00000124672.2, ENSMUST00000160682.8
      Conserved Domains (1) summary
      cd01791
      Location:1 → 71
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

    3. NM_001361026.1 → NP_001347955.1  ubiquitin-like protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK009854, CD350466
      Consensus CDS
      CCDS90506.1
      UniProtKB/TrEMBL
      E0CY38
      Related
      ENSMUSP00000124506.2, ENSMUST00000161486.8
      Conserved Domains (1) summary
      cl00155
      Location:1 → 50
      UBQ; Ubiquitin-like proteins

    4. NM_001361027.1 → NP_001347956.1  ubiquitin-like protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164565, AK009854, BF472858, BU705105
      Consensus CDS
      CCDS52733.1
      UniProtKB/Swiss-Prot
      Q9EPV8
      Related
      ENSMUSP00000124812.2, ENSMUST00000162303.8
      Conserved Domains (1) summary
      cd01791
      Location:1 → 71
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

    5. NM_025401.4 → NP_079677.1  ubiquitin-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_079677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK051149, BU705105
      Consensus CDS
      CCDS52733.1
      UniProtKB/Swiss-Prot
      Q9EPV8
      Related
      ENSMUSP00000123971.2, ENSMUST00000129414.9
      Conserved Domains (1) summary
      cd01791
      Location:1 → 71
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

    RNA

    1. NR_153857.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164565
      Related
      ENSMUST00000154429.9

    2. NR_153858.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164565, AK009854, BU705105, CJ041902
      Related
      ENSMUST00000160874.8

    3. NR_153859.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164565

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20554013..20558436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPV8.1 GenPept UniProtKB/Swiss-Prot:Q9EPV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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