Trpc1 transient receptor potential cation channel, subfamily C, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc1provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 1provided by MGI
Primary source: MGI:MGI:109528
See related: Ensembl:ENSMUSG00000032839 AllianceGenome:MGI:109528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trp1; Mtrp1; Trrp1
Summary: Enables store-operated calcium channel activity. Acts upstream of or within saliva secretion. Located in basolateral plasma membrane; membrane raft; and myofibril. Part of protein-containing complex. Is expressed in cochlea; dorsal root ganglion; skeletal muscle; spinal cord; and vagus ganglion. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 4.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 50.2 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (95587125..95632438, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (95705072..95750386, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice.
Title: Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice.
Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke.
Title: Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke.
Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).
Title: Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).
TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Muller cells.
Title: TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells.
Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities.
Title: Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities.
TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
Title: TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
Store-operated Ca(2+) entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
Title: Store-operated Ca(2+) entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
Loss of Ca(2+) entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages.
Title: Loss of Ca(2+) entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages.
These results suggest an unequivocal role of TRPC1 in adipocyte differentiation and adiponectin secretion, and that loss of TRPC1 disturbs metabolic homeostasis.
Title: Ca(2+) entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex.
Stimulation of calcium-sensing receptors activates heteromeric TRPV4/TRPC1 channels and NO production in endothelial cells, which are responsible for endothelium-dependent vasorelaxations.
Title: Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1(-/-) mice.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc1 (e-PCR), detects polymorphism
- UniSTS:531238

Trrp1 (e-PCR), detects polymorphism
- UniSTS:144682

Trpc1 (e-PCR), detects polymorphism
- UniSTS:516709

Trpc1 (e-PCR), detects polymorphism
- UniSTS:516710

UniSTS:236220 (e-PCR)
- UniSTS:236220

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info	PubMed
enables store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within saliva secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: short transient receptor potential channel 1

Names: transient receptor protein 1; trp-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311123.2 → NP_001298052.2 short transient receptor potential channel 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC091531, AC157947

Consensus CDS

CCDS81052.1

Related

ENSMUSP00000057640.5, ENSMUST00000053785.10

Conserved Domains (2) summary

TIGR00870
Location:48 → 740

trp; transient-receptor-potential calcium channel protein

sd00045
Location:83 → 117

ANK; ANK repeat [structural motif]
NM_001413351.1 → NP_001400280.1 short transient receptor potential channel 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC091531, AC157947
NM_001413352.1 → NP_001400281.1 short transient receptor potential channel 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC091531, AC157947
NM_001413353.1 → NP_001400282.1 short transient receptor potential channel 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC091531, AC157947
NM_001413354.1 → NP_001400283.1 short transient receptor potential channel 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC091531, AC157947
NM_011643.4 → NP_035773.2 short transient receptor potential channel 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC091531, AC157947

Consensus CDS

CCDS23411.1

UniProtKB/Swiss-Prot

O35722, Q61056

Related

ENSMUSP00000139672.2, ENSMUST00000189137.7

Conserved Domains (1) summary

TIGR00870
Location:48 → 774

trp; transient-receptor-potential calcium channel protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

95587125..95632438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244242.2 → XP_030100102.1 short transient receptor potential channel 1 isoform X4

Conserved Domains (1) summary

TIGR00870
Location:12 → 622

trp; transient-receptor-potential calcium channel protein
XM_006511057.3 → XP_006511120.1 short transient receptor potential channel 1 isoform X5

Conserved Domains (1) summary

TIGR00870
Location:12 → 629

trp; transient-receptor-potential calcium channel protein
XM_030244244.2 → XP_030100104.1 short transient receptor potential channel 1 isoform X8

Conserved Domains (1) summary

TIGR00870
Location:36 → 377

trp; transient-receptor-potential calcium channel protein
XM_030244243.1 → XP_030100103.1 short transient receptor potential channel 1 isoform X6

Conserved Domains (1) summary

TIGR00870
Location:64 → 598

trp; transient-receptor-potential calcium channel protein
XM_011242717.4 → XP_011241019.1 short transient receptor potential channel 1 isoform X7

Conserved Domains (1) summary

TIGR00870
Location:64 → 413

trp; transient-receptor-potential calcium channel protein