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    Prrc2a proline-rich coiled-coil 2A [ Mus musculus (house mouse) ]

    Gene ID: 53761, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrc2aprovided by MGI
    Official Full Name
    proline-rich coiled-coil 2Aprovided by MGI
    Primary source
    MGI:MGI:1915467
    See related
    Ensembl:ENSMUSG00000024393 AllianceGenome:MGI:1915467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G2; Bat2; Bat-2; Wbp12; D17H6S51E; mKIAA4178; 3110039B05Rik
    Summary
    Predicted to be involved in cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 97.6), adrenal adult (RPKM 89.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrc2a in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35368052..35384877, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35149076..35165321, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5599 Neighboring gene apolipoprotein M Neighboring gene BCL2-associated athanogene 6 Neighboring gene STARR-positive B cell enhancer ABC_E3201 Neighboring gene STARR-positive B cell enhancer ABC_E2486 Neighboring gene predicted gene, 23442 Neighboring gene STARR-positive B cell enhancer ABC_E5600 Neighboring gene allograft inflammatory factor 1 Neighboring gene natural cytotoxicity triggering receptor 3, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination. Wu R, et al. Cell Res, 2019 Jan. PMID 30514900, Free PMC Article
    2. Fine mapping of the crossover-sites in the C4-H-2D region of H-2 recombinant mouse strains. Snoek M, et al. Immunogenetics, 1991. PMID 1684177
    3. Identification of a recombinational breakpoint at the BAT5 locus in three intra-H-2 recombinant inbred mouse strains. Mathew PA, et al. Exp Clin Immunogenet, 1995. PMID 8919359
    4. RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. Lund T, et al. Diabetologia, 1993 Aug. PMID 8104833
    5. Localization of the casein kinase II beta-subunit gene within the mouse H-2 complex class III region and comparison of expression with Bat genes. Lanning D, et al. Mamm Genome, 1997 Jul. PMID 9196000

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4178

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2A
    Names
    HLA-B associated transcript 2
    large proline-rich protein BAT2
    proline-rich and coiled-coil-containing protein 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199044.1 → NP_001185973.1  protein PRRC2A isoform 2

      See identical proteins and their annotated locations for NP_001185973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      BC052630, BC053522, CJ107441
      UniProtKB/TrEMBL
      G3UX48
      Related
      ENSMUSP00000133550.2, ENSMUST00000174805.2
      Conserved Domains (2) summary
      PHA03247
      Location:1475 → 1899
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    2. NM_020027.3 → NP_064411.2  protein PRRC2A isoform 1

      See identical proteins and their annotated locations for NP_064411.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC053522, CJ107441
      Consensus CDS
      CCDS37596.1
      UniProtKB/Swiss-Prot
      Q7TSC1, Q923A9, Q9Z1R1
      UniProtKB/TrEMBL
      G3UX48
      Related
      ENSMUSP00000025253.6, ENSMUST00000025253.12
      Conserved Domains (2) summary
      PHA03247
      Location:1475 → 1900
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 186
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35368052..35384877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249899.2 → XP_030105759.1  protein PRRC2A isoform X2

      UniProtKB/TrEMBL
      G3UX48
      Conserved Domains (2) summary
      PHA03247
      Location:1475 → 1899
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    2. XM_006524620.5 → XP_006524683.1  protein PRRC2A isoform X1

      See identical proteins and their annotated locations for XP_006524683.1

      UniProtKB/Swiss-Prot
      Q7TSC1, Q923A9, Q9Z1R1
      UniProtKB/TrEMBL
      G3UX48
      Conserved Domains (2) summary
      PHA03247
      Location:1475 → 1900
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 186
      BAT2_N; BAT2 N-terminus

    3. XM_030249900.1 → XP_030105760.1  protein PRRC2A isoform X3

      UniProtKB/TrEMBL
      G3UX48
      Conserved Domains (2) summary
      PHA03247
      Location:1465 → 1890
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 177
      BAT2_N; BAT2 N-terminus

    4. XM_006524621.5 → XP_006524684.1  protein PRRC2A isoform X3

      See identical proteins and their annotated locations for XP_006524684.1

      UniProtKB/TrEMBL
      G3UX48
      Conserved Domains (2) summary
      PHA03247
      Location:1465 → 1890
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 177
      BAT2_N; BAT2 N-terminus

    RNA

    1. XR_004939552.1 RNA Sequence

    2. XR_004939551.1 RNA Sequence

    3. XR_004939553.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSC1.1 GenPept UniProtKB/Swiss-Prot:Q7TSC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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