Hnrnpab heterogeneous nuclear ribonucleoprotein A/B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpabprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein A/Bprovided by MGI
Primary source: MGI:MGI:1330294
See related: Ensembl:ENSMUSG00000020358 AllianceGenome:MGI:1330294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CBF-A; Cgbfa; Hnrpab; 3010025C11Rik
Summary: This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in ovary adult (RPKM 222.6), CNS E11.5 (RPKM 200.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.11 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (51490927..51497708, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (51600100..51606881, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hnRNPAB inhibits Influenza A virus infection by disturbing polymerase activity.
Title: hnRNPAB inhibits Influenza A virus infection by disturbing polymerase activity.
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons.
Title: Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons.
Scrutinized the motility of Hnrnpab(-/-) cells and confirmed that the decreases in both cell motility and Eps8 are restored by ectopically coexpressing both alternatively spliced Hnrnpab isoforms, therefore these variants are surprisingly nonredundant for cell motility.
Title: Hnrnpab regulates neural cell motility through transcription of Eps8.
We suggest that CBF-A plays an important role in spermatogenesis by regulating stage-specific translation of testicular mRNAs.
Title: The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis.
Hnrpab(-/-) neural stem and progenitor cells undergo altered differentiation patterns in culture, and mature Hnrpab(-/-) neurons demonstrate increased sensitivity to glutamate-induced excitotoxicity
Title: Hnrpab regulates neural development and neuron cell survival after glutamate stimulation.
Expressing Hnrpab into two different cell lines, their growth was suppressed, demonstrating that this protein has cytostatic activity.
Title: Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.
Although CRP2 expression during development is independent of CArG box, its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors.
Title: Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature.
role of S-nitrosylation in osteopontin transcription regulation in macrophages
Title: S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages.
structure and binding of CBF-A (AUF2)
Title: Identification of a novel AU-rich-element-binding protein which is related to AUF1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrpab (e-PCR), detects polymorphism
- UniSTS:479005

AI585872 (e-PCR)
- UniSTS:180195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosomal 5-methylcytosine DNA demethylation pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular mRNA localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of mRNA editing complex	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein A/B

Names: CArG-binding factor-A; S1 protein D2; hnRNP A/B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048061.1 → NP_001041526.1 heterogeneous nuclear ribonucleoprotein A/B isoform 1

See identical proteins and their annotated locations for NP_001041526.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AL645602, BQ445737, CA325334, CF751043, CJ166869

Consensus CDS

CCDS48787.1

UniProtKB/TrEMBL

Q20BD0, Q3TMZ8

Related

ENSMUSP00000104731.4, ENSMUST00000109103.4

Conserved Domains (3) summary

cd12584
Location:155 → 234

RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins

cd12757
Location:76 → 150

RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins

pfam08143
Location:1 → 75

CBFNT; CBFNT (NUC161) domain
NM_010448.3 → NP_034578.1 heterogeneous nuclear ribonucleoprotein A/B isoform 2

See identical proteins and their annotated locations for NP_034578.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AK013384, CJ166869

Consensus CDS

CCDS24654.1

UniProtKB/Swiss-Prot

Q8BPE0, Q99020

UniProtKB/TrEMBL

Q3TMZ8, Q544Z3

Related

ENSMUSP00000074238.4, ENSMUST00000074669.10

Conserved Domains (3) summary

cd12757
Location:76 → 150

RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins

pfam08143
Location:1 → 75

CBFNT; CBFNT (NUC161) domain

cl17169
Location:155 → 234

RRM_SF; RNA recognition motif (RRM) superfamily