Wdr1 WD repeat domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr1provided by MGI
Official Full Name: WD repeat domain 1provided by MGI
Primary source: MGI:MGI:1337100
See related: Ensembl:ENSMUSG00000005103 AllianceGenome:MGI:1337100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aip1; rede; D5Wsu185e
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including cytoskeleton organization; establishment of planar polarity of follicular epithelium; and platelet formation. Acts upstream of or within positive regulation of actin filament depolymerization; regulation of ventricular cardiac muscle cell membrane repolarization; and sarcomere organization. Located in myelin sheath. Is active in glutamatergic synapse. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; heart; and telencephalon. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 105.0), bladder adult (RPKM 95.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.63 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (38684149..38720265, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (38526806..38562922, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation.
Title: WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation.
Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice.
Title: Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice.
Wdr1 gene deletion in germ cells can influence early ovarian function of mice and lead to premature ovarian failure.
Title: [Effect of germ cell Wdr1 deletion on the ovarian function of mice].
Findings demonstrate that WDR1 is a critical factor for normal structure and function of adult mouse heart.
Title: Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.
Following platelets spreading on fibrinogen substrate, Wdr-1 translocates to the cytoskeleton in association with cofilin-1. In Wdr-1-deficient platelets, cofilin-1 is aberrantly localized throughout the cytoplasm and there is no significant change following adhesion to fibrinogen substrate.
Title: Wdr-1 is essential for F-actin interaction with focal adhesions in platelets.
essential for talin-induced activation of alphaIIbbeta3 during platelet activation
Title: Wdr1-Dependent Actin Reorganization in Platelet Activation.
WDR1 interacts with Lim domain kinase 1 (LIMK1), a well known phosphorylation kinase of Cofilin.
Title: Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation.
Wdr1 and cofilin/destrin-mediated actomyosin remodelling are essential for generating or maintaining cortical tension within the developing epidermal sheet and driving the cell shape and planar orientation changes.
Title: Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.
Wdr1-regulated actin dynamics play essential roles in heart function in mice. F-actin accumulations caused by Wdr1 deletion result in disruption of sarcomeric structure.
Title: A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.
The QKI RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1.
Title: The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128182 (e-PCR)
- UniSTS:211490

RH124799 (e-PCR)
- UniSTS:161621

D5Wsu185e (e-PCR), detects polymorphism
- UniSTS:142571

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info	PubMed
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament fragmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical junction assembly	IEA Inferred from Electronic Annotation more info
involved_in apical junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cortical cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in maintenance of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in neutrophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament depolymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 1

Names: WD40 repeat protein 1; actin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011715.3 → NP_035845.1 WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_035845.1

Status: VALIDATED

Source sequence(s)

AC084322, AC171271

Consensus CDS

CCDS51485.1

UniProtKB/Swiss-Prot

O88342

UniProtKB/TrEMBL

Q3TJY2, Q9DBM8, Q9DC08

Related

ENSMUSP00000005234.10, ENSMUST00000005234.13

Conserved Domains (4) summary

COG2319
Location:53 → 475

WD40; WD40 repeat [General function prediction only]

cd00200
Location:54 → 389

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:62 → 100

7WD40; WD40 repeat [structural motif]

cl02567
Location:312 → 602

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

38684149..38720265 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503863.5 → XP_006503926.1 WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

Q3TE06

Conserved Domains (3) summary

cd00200
Location:54 → 389

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:62 → 100

7WD40; WD40 repeat [structural motif]

cl29593
Location:312 → 521

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...