Btrc beta-transducin repeat containing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btrcprovided by MGI
Official Full Name: beta-transducin repeat containing proteinprovided by MGI
Primary source: MGI:MGI:1338871
See related: Ensembl:ENSMUSG00000025217 AllianceGenome:MGI:1338871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HOS; FWD1; Fbw1a; Slimb; b-TrCP; beta-TrCP; Beta-Trcp1; SCF b-TRCP; E3RSIkappaB; E3RS-IkappaB
Summary: Enables beta-catenin binding activity; protein phosphorylated amino acid binding activity; and ubiquitin protein ligase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein dephosphorylation; and regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including mammary gland epithelium development; protein K48-linked ubiquitination; and regulation of canonical NF-kappaB signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system; and respiratory system. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E18 (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.75 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (45352119..45521782)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (45363688..45533343)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel targets of beta-TrCP cooperatively accelerate carbohydrate and fatty acid consumption.
Title: Novel targets of β-TrCP cooperatively accelerate carbohydrate and fatty acid consumption.
Specific targeting of the NRF2/beta-TrCP axis promotes beneficial effects in NASH.
Title: Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH.
Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.
Title: Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.
circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
Title: circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
The beta-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo.
Title: The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo.
MK2 promotes Tfcp2l1 degradation via beta-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
Title: MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
The role of SCF(Skp2) and SCF(beta-TrCP1/2) in the cerebellar granule cell precursors.
Title: The role of SCF(Skp2) and SCF(β-TrCP1/2) in the cerebellar granule cell precursors.
Results show that PARP11 mono-ADP-ribosylates beta-TrCP which promotes IFNAR1 ubiquitination and degradation.
Title: ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
Study findings identify beta-TrCP as an important negative regulator for upstream signaling of IkappaBalpha in lipopolysaccharide pathway, and therefore renew the understanding of the roles of beta-TrCP in regulating toll-like receptors inflammatory signaling.
Title: β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
Investigated beta-TrCP function in Sertoli cells by generating mice with targeted deletion of the beta-TrCP2 gene in Sertoli cells on a background of whole-body beta-TrCP1 knockout. Loss of beta-TrCP in Sertoli cells caused infertility due to a reduction in the number of mature sperm.
Title: The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Btrc (e-PCR), detects polymorphism
- UniSTS:545904

Btrc (e-PCR), detects polymorphism
- UniSTS:506756

NoName (e-PCR)
- UniSTS:237958

NoName (e-PCR)
- UniSTS:237960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein phosphorylated amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin ligase activator activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-box/WD repeat-containing protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037758.2 → NP_001032847.2 F-box/WD repeat-containing protein 1A isoform a

See identical proteins and their annotated locations for NP_001032847.2

Status: VALIDATED

Source sequence(s)

AC126454, AK052317, AK145624, BP768842, BY070850, BY290279

Consensus CDS

CCDS29860.1

UniProtKB/Swiss-Prot

Q3U0Q4, Q3ULA2, Q571K6, Q9QUI5, Q9R1G7, Q9Z159

Related

ENSMUSP00000070728.6, ENSMUST00000065601.13

Conserved Domains (5) summary

COG2319
Location:290 → 586

WD40; WD40 repeat [General function prediction only]

cd00200
Location:303 → 581

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:139 → 177

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:181 → 228

F-box-like; F-box-like

sd00039
Location:306 → 341

7WD40; WD40 repeat [structural motif]
NM_001286465.1 → NP_001273394.1 F-box/WD repeat-containing protein 1A isoform a

See identical proteins and their annotated locations for NP_001273394.1

Status: VALIDATED

Source sequence(s)

AC126454, AK052317, AK145624, BP768842, BY070850, BY290279

Consensus CDS

CCDS29860.1

UniProtKB/Swiss-Prot

Q3U0Q4, Q3ULA2, Q571K6, Q9QUI5, Q9R1G7, Q9Z159

Conserved Domains (5) summary

COG2319
Location:290 → 586

WD40; WD40 repeat [General function prediction only]

cd00200
Location:303 → 581

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:139 → 177

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:181 → 228

F-box-like; F-box-like

sd00039
Location:306 → 341

7WD40; WD40 repeat [structural motif]
NM_001286466.1 → NP_001273395.1 F-box/WD repeat-containing protein 1A isoform c

Status: VALIDATED

Source sequence(s)

AC126454, AK052317, AK145624, BP768842, BY070850, BY290279

UniProtKB/Swiss-Prot

Q3ULA2

Conserved Domains (3) summary

COG2319
Location:68 → 364

WD40; WD40 repeat [General function prediction only]

cd00200
Location:81 → 359

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:84 → 119

7WD40; WD40 repeat [structural motif]
NM_001360120.1 → NP_001347049.1 F-box/WD repeat-containing protein 1A isoform d

Status: VALIDATED

Source sequence(s)

AC123058, AC126454, BP768842

Conserved Domains (4) summary

cd00200
Location:317 → 595

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:320 → 355

7WD40; WD40 repeat [structural motif]

pfam12125
Location:153 → 191

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:195 → 242

F-box-like
NM_001360122.1 → NP_001347051.1 F-box/WD repeat-containing protein 1A isoform e

Status: VALIDATED

Source sequence(s)

AC123058, AC126454, BP768842

Conserved Domains (4) summary

cd00200
Location:291 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:294 → 329

7WD40; WD40 repeat [structural motif]

pfam12125
Location:127 → 165

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:169 → 216

F-box-like
NM_001360124.1 → NP_001347053.1 F-box/WD repeat-containing protein 1A isoform f

Status: VALIDATED

Source sequence(s)

AC123058, AC126454, BP768842

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
NM_001360126.1 → NP_001347055.1 F-box/WD repeat-containing protein 1A isoform g

Status: VALIDATED

Source sequence(s)

AC123058, AC126454, BP768842

Conserved Domains (4) summary

cd00200
Location:281 → 559

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:284 → 319

7WD40; WD40 repeat [structural motif]

pfam12125
Location:117 → 155

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:159 → 206

F-box-like; F-box-like
NM_001360127.1 → NP_001347056.1 F-box/WD repeat-containing protein 1A isoform h

Status: VALIDATED

Source sequence(s)

AC123058, AC126454, BP768842

Conserved Domains (4) summary

cd00200
Location:277 → 555

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:280 → 315

7WD40; WD40 repeat [structural motif]

pfam12125
Location:113 → 151

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:155 → 202

F-box-like; F-box-like
NM_001409992.1 → NP_001396921.1 F-box/WD repeat-containing protein 1A isoform f

Status: VALIDATED

Source sequence(s)

AC123058, AC126454
NM_009771.3 → NP_033901.1 F-box/WD repeat-containing protein 1A isoform b

See identical proteins and their annotated locations for NP_033901.1

Status: VALIDATED

Source sequence(s)

AC126454, AK052317, AK145624, BP768842, BY070850, BY290279

Consensus CDS

CCDS38002.1

UniProtKB/Swiss-Prot

Q3ULA2

Related

ENSMUSP00000107567.3, ENSMUST00000111936.4

Conserved Domains (5) summary

COG2319
Location:254 → 550

WD40; WD40 repeat [General function prediction only]

cd00200
Location:267 → 545

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12125
Location:103 → 141

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:145 → 192

F-box-like; F-box-like

sd00039
Location:270 → 305

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

45352119..45521782

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247119.4 → XP_011245421.1 F-box/WD repeat-containing protein 1A isoform X3

Conserved Domains (4) summary

cd00200
Location:287 → 565

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:290 → 325

7WD40; WD40 repeat [structural motif]

pfam12125
Location:123 → 161

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:165 → 212

F-box-like
XM_036161407.1 → XP_036017300.1 F-box/WD repeat-containing protein 1A isoform X3

Conserved Domains (4) summary

cd00200
Location:287 → 565

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:290 → 325

7WD40; WD40 repeat [structural motif]

pfam12125
Location:123 → 161

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:165 → 212

F-box-like
XM_006526614.5 → XP_006526677.2 F-box/WD repeat-containing protein 1A isoform X7

Conserved Domains (4) summary

cd00200
Location:261 → 539

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:264 → 299

7WD40; WD40 repeat [structural motif]

pfam12125
Location:97 → 135

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:139 → 186

F-box-like
XM_030250718.2 → XP_030106578.1 F-box/WD repeat-containing protein 1A isoform X11

Conserved Domains (4) summary

cd00200
Location:251 → 529

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:254 → 289

7WD40; WD40 repeat [structural motif]

pfam12125
Location:87 → 125

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:129 → 176

F-box-like
XM_011247123.4 → XP_011245425.1 F-box/WD repeat-containing protein 1A isoform X9

Conserved Domains (4) summary

cd00200
Location:255 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:258 → 293

7WD40; WD40 repeat [structural motif]

pfam12125
Location:91 → 129

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:133 → 180

F-box-like
XM_036161413.1 → XP_036017306.1 F-box/WD repeat-containing protein 1A isoform X9

Conserved Domains (4) summary

cd00200
Location:255 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:258 → 293

7WD40; WD40 repeat [structural motif]

pfam12125
Location:91 → 129

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:133 → 180

F-box-like
XM_030250714.2 → XP_030106574.1 F-box/WD repeat-containing protein 1A isoform X6

Conserved Domains (4) summary

cd00200
Location:273 → 551

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:276 → 311

7WD40; WD40 repeat [structural motif]

pfam12125
Location:109 → 147

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:151 → 198

F-box-like
XM_030250719.2 → XP_030106579.1 F-box/WD repeat-containing protein 1A isoform X12

Conserved Domains (4) summary

cd00200
Location:247 → 525

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:250 → 285

7WD40; WD40 repeat [structural motif]

pfam12125
Location:83 → 121

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:125 → 172

F-box-like
XM_006526613.4 → XP_006526676.1 F-box/WD repeat-containing protein 1A isoform X14

Conserved Domains (4) summary

cd00200
Location:237 → 515

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:240 → 275

7WD40; WD40 repeat [structural motif]

pfam12125
Location:73 → 111

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:115 → 162

F-box-like
XM_006526612.4 → XP_006526675.1 F-box/WD repeat-containing protein 1A isoform X13

Conserved Domains (4) summary

cd00200
Location:241 → 519

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:244 → 279

7WD40; WD40 repeat [structural motif]

pfam12125
Location:77 → 115

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:119 → 166

F-box-like
XM_036161405.1 → XP_036017298.1 F-box/WD repeat-containing protein 1A isoform X1

Conserved Domains (4) summary

cd00200
Location:317 → 595

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:320 → 355

7WD40; WD40 repeat [structural motif]

pfam12125
Location:153 → 191

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:195 → 242

F-box-like
XM_036161406.1 → XP_036017299.1 F-box/WD repeat-containing protein 1A isoform X2

Conserved Domains (4) summary

cd00200
Location:291 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:294 → 329

7WD40; WD40 repeat [structural motif]

pfam12125
Location:127 → 165

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:169 → 216

F-box-like
XM_030250713.2 → XP_030106573.1 F-box/WD repeat-containing protein 1A isoform X4

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_030250721.2 → XP_030106581.1 F-box/WD repeat-containing protein 1A isoform X15

UniProtKB/TrEMBL

A0A286YDT6

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_036161408.1 → XP_036017301.1 F-box/WD repeat-containing protein 1A isoform X4

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_030250711.1 → XP_030106571.1 F-box/WD repeat-containing protein 1A isoform X4

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_030250715.1 → XP_030106575.1 F-box/WD repeat-containing protein 1A isoform X8

Conserved Domains (4) summary

cd00200
Location:259 → 537

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:262 → 297

7WD40; WD40 repeat [structural motif]

pfam12125
Location:95 → 133

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:137 → 184

F-box-like
XM_030250720.1 → XP_030106580.1 F-box/WD repeat-containing protein 1A isoform X15

UniProtKB/TrEMBL

A0A286YDT6

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_036161409.1 → XP_036017302.1 F-box/WD repeat-containing protein 1A isoform X4

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_036161412.1 → XP_036017305.1 F-box/WD repeat-containing protein 1A isoform X10

Conserved Domains (4) summary

cd00200
Location:255 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:258 → 293

7WD40; WD40 repeat [structural motif]

pfam12125
Location:91 → 129

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:133 → 180

F-box-like
XM_030250716.1 → XP_030106576.1 F-box/WD repeat-containing protein 1A isoform X10

Conserved Domains (4) summary

cd00200
Location:255 → 533

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:258 → 293

7WD40; WD40 repeat [structural motif]

pfam12125
Location:91 → 129

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:133 → 180

F-box-like
XM_030250712.1 → XP_030106572.1 F-box/WD repeat-containing protein 1A isoform X4

Conserved Domains (4) summary

cd00200
Location:285 → 563

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:288 → 323

7WD40; WD40 repeat [structural motif]

pfam12125
Location:121 → 159

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:163 → 210

F-box-like
XM_036161410.1 → XP_036017303.1 F-box/WD repeat-containing protein 1A isoform X8

Conserved Domains (4) summary

cd00200
Location:259 → 537

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:262 → 297

7WD40; WD40 repeat [structural motif]

pfam12125
Location:95 → 133

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:137 → 184

F-box-like
XM_036161411.1 → XP_036017304.1 F-box/WD repeat-containing protein 1A isoform X8

Conserved Domains (4) summary

cd00200
Location:259 → 537

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:262 → 297

7WD40; WD40 repeat [structural motif]

pfam12125
Location:95 → 133

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:137 → 184

F-box-like
XM_011247127.3 → XP_011245429.1 F-box/WD repeat-containing protein 1A isoform X15

See identical proteins and their annotated locations for XP_011245429.1

UniProtKB/TrEMBL

A0A286YDT6

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_030250722.1 → XP_030106582.1 F-box/WD repeat-containing protein 1A isoform X15

UniProtKB/TrEMBL

A0A286YDT6

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like
XM_011247121.4 → XP_011245423.1 F-box/WD repeat-containing protein 1A isoform X5

Conserved Domains (4) summary

cd00200
Location:282 → 560

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:285 → 320

7WD40; WD40 repeat [structural motif]

pfam12125
Location:118 → 156

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:160 → 207

F-box-like
XM_006526615.3 → XP_006526678.1 F-box/WD repeat-containing protein 1A isoform X15

See identical proteins and their annotated locations for XP_006526678.1

UniProtKB/TrEMBL

A0A286YDT6

Related

ENSMUSP00000153562.2, ENSMUST00000224478.2

Conserved Domains (4) summary

cd00200
Location:204 → 482

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:207 → 242

7WD40; WD40 repeat [structural motif]

pfam12125
Location:40 → 78

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:82 → 129

F-box-like