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    Sec11a SEC11 homolog A, signal peptidase complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 56529, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sec11aprovided by MGI
    Official Full Name
    SEC11 homolog A, signal peptidase complex subunitprovided by MGI
    Primary source
    MGI:MGI:1929464
    See related
    Ensembl:ENSMUSG00000025724 AllianceGenome:MGI:1929464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    18kDa; Spc18; Sec11l1; sid2895; Sid2895p; 1810012E07Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 78.7), limb E14.5 (RPKM 45.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec11a in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80565125..80597295, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80915379..80947550, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B Neighboring gene predicted gene, 51451 Neighboring gene STARR-positive B cell enhancer ABC_E2829 Neighboring gene STARR-seq mESC enhancer starr_19348 Neighboring gene predicted gene, 32178 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene zinc finger protein 592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal peptide processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal peptidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex catalytic subunit SEC11A
    Names
    SEC11-like protein 1
    SPase 18 kDa subunit
    Sec11-like 1
    endopeptidase SP18
    microsomal signal peptidase 18 kDa subunit
    sid 2895
    signal peptidase complex (18kD)
    NP_001405484.1
    NP_001405485.1
    NP_001405486.1
    NP_001405487.1
    NP_001405488.1
    NP_064335.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418555.1 → NP_001405484.1  signal peptidase complex catalytic subunit SEC11A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123744

    2. NM_001418556.1 → NP_001405485.1  signal peptidase complex catalytic subunit SEC11A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123744
      UniProtKB/TrEMBL
      D3Z569
      Related
      ENSMUSP00000113601.2, ENSMUST00000117383.8

    3. NM_001418557.1 → NP_001405486.1  signal peptidase complex catalytic subunit SEC11A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123744

    4. NM_001418558.1 → NP_001405487.1  signal peptidase complex catalytic subunit SEC11A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC123744

    5. NM_001418559.1 → NP_001405488.1  signal peptidase complex catalytic subunit SEC11A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC123744

    6. NM_019951.2 → NP_064335.1  signal peptidase complex catalytic subunit SEC11A isoform 1

      See identical proteins and their annotated locations for NP_064335.1

      Status: VALIDATED

      Source sequence(s)
      AC123744
      Consensus CDS
      CCDS21401.1
      UniProtKB/Swiss-Prot
      Q9R0P6
      UniProtKB/TrEMBL
      D3YWT0
      Related
      ENSMUSP00000026818.6, ENSMUST00000026818.12
      Conserved Domains (1) summary
      cl10465
      Location:38 → 150
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80565125..80597295 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0P6.1 GenPept UniProtKB/Swiss-Prot:Q9R0P6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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