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    B4galt2 beta-1,4-galactosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313536, updated on 2-Nov-2024

    Summary

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    Official Symbol
    B4galt2provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 2provided by RGD
    Primary source
    RGD:1305358
    See related
    EnsemblRapid:ENSRNOG00000019609 AllianceGenome:RGD:1305358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable galactosyltransferase activity. Predicted to be involved in glycosylation. Predicted to act upstream of or within cerebellar Purkinje cell layer development; learning or memory; and locomotory behavior. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT2 (beta-1,4-galactosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 84.6), Lung (RPKM 31.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galt2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136697981..136707783, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131412541..131422573, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136707510..136717345, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 17 Neighboring gene solute carrier family 6 member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene uncharacterized LOC120102957 Neighboring gene ATPase H+ transporting V0 subunit B Neighboring gene diphthamide biosynthesis 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Yoshihara T, et al. J Biol Chem, 2009 May 1. PMID 19265195, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 2
    Names
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
    NP_001101435.1
    XP_006238729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107965.1 → NP_001101435.1  beta-1,4-galactosyltransferase 2

      See identical proteins and their annotated locations for NP_001101435.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474008
      UniProtKB/TrEMBL
      A6JZE9, D4A2A5
      Related
      ENSRNOP00000026591.4, ENSRNOT00000026591.8
      Conserved Domains (1) summary
      cd00899
      Location:142 → 358
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      136697981..136707783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238667.5 → XP_006238729.1  beta-1,4-galactosyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006238729.1

      UniProtKB/TrEMBL
      A6JZE9, D4A2A5
      Conserved Domains (1) summary
      cd00899
      Location:142 → 358
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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