Keap1 Keap1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Keap1provided by FlyBase
Official Full Name: Keap1provided by FlyBase
Primary source: FLYBASE:FBgn0038475
Locus tag: Dmel_CG3962
See related: AllianceGenome:FB:FBgn0038475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3962; dkeap-1; dkeap1; dKeap1; dKEAP1; Dmel\CG3962; DmKeap1; keap; keap-1; Keap-1; keap1; KEAP1; nrf-2; Nrf-2
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; response to oxidative stress; and reticulophagy. Located in nucleus and polytene chromosome puff. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including amnioserosa; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 89E11-89E12; 3-59 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17073942..17079945, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12899664..12905667, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
Title: Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture.
PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Title: PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development.
Macrophage Nrf 2 the rescue.
Title: Macrophage Nrf 2 the rescue.
Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin.
Title: Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin.
Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.
Title: Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data.
Together with the facts that Maf-S regulates ROS levels and genetically interacts with Keap1/Nrf2 in GSC maintenance, our study suggests that Maf-S plays an important role in the Drosophila testis GSC maintenance by participating in the regulation of redox homeost
Title: Small Maf functions in the maintenance of germline stem cells in the Drosophila testis.
Data suggest that blocking the specific interaction of Nrf2/cncC (cap-n-collar isoform C) with Keap1 may provide an exciting new avenue for the discovery of disease-modifying treatments for Alzheimer's disease (AD) and potentially other neurodegenerative conditions.
Title: Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Consistent with the independent modes of CncC regulation by Keap1 and Fs(1)h, combinations of drugs that can specifically target these pathways cause a strong synergistic and specific activation of protective CncC- dependent gene expression and boosts oxidative stress resistance.
Title: Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.
cooperatively activate developmental genes, in contrast to their conserved antagonizing effect to xenobiotic response transcription
Title: Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.
dKeap1 and CncC have a xenobiotic-specific gene activation response due to their combinatorial chromatin-binding specificities and transcriptional activities
Title: Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Keap1

Names: CG3962-PA; CG3962-PB; CG3962-PC; Keap1-PA; Keap1-PB; Keap1-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

17073942..17079945 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176508.3 → NP_788685.1 Keap1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788685.1

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q9VEN5

Related

FBpp0082865

Conserved Domains (6) summary

smart00612
Location:446 → 491

Kelch; Kelch domain

PHA03098
Location:60 → 567

PHA03098; kelch-like protein; Provisional

sd00038
Location:435 → 478

Kelch; KELCH repeat [structural motif]

pfam00651
Location:48 → 151

BTB; BTB/POZ domain

pfam01344
Location:482 → 524

Kelch_1; Kelch motif

pfam07707
Location:160 → 262

BACK; BTB And C-terminal Kelch
NM_142337.3 → NP_650594.1 Keap1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650594.1

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q9VEN5

Related

FBpp0082863

Conserved Domains (6) summary

smart00612
Location:446 → 491

Kelch; Kelch domain

PHA03098
Location:60 → 567

PHA03098; kelch-like protein; Provisional

sd00038
Location:435 → 478

Kelch; KELCH repeat [structural motif]

pfam00651
Location:48 → 151

BTB; BTB/POZ domain

pfam01344
Location:482 → 524

Kelch_1; Kelch motif

pfam07707
Location:160 → 262

BACK; BTB And C-terminal Kelch
NM_169744.3 → NP_732202.2 Keap1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732202.2

Status: REVIEWED

UniProtKB/TrEMBL

A9UNI1, Q7KSF5

Related

FBpp0082864

Conserved Domains (6) summary

smart00612
Location:478 → 523

Kelch; Kelch domain

PHA03098
Location:92 → 599

PHA03098; kelch-like protein; Provisional

sd00038
Location:467 → 510

Kelch; KELCH repeat [structural motif]

pfam00651
Location:80 → 183

BTB; BTB/POZ domain

pfam01344
Location:514 → 556

Kelch_1; Kelch motif

pfam07707
Location:192 → 294

BACK; BTB And C-terminal Kelch