BicC Bicaudal C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BicCprovided by FlyBase
Official Full Name: Bicaudal Cprovided by FlyBase
Primary source: FLYBASE:FBgn0000182
Locus tag: Dmel_CG4824
See related: AllianceGenome:FB:FBgn0000182
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS00913.2; Bic-C; bicC; BICC; br34; CG4824; Dmel\CG4824; Dromel_CG4824_FBtr0080804_bicc_mORF; l(2)br34
Summary: Enables mRNA binding activity. Involved in actin cytoskeleton organization and microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in germarium region 2a; germarium region 2b; germarium region 3; nurse cell; and oocyte. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35E2-35E2; 2-51 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16042047..16048757)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16042047..16048757)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired BicC function induces renal cystogenesis in Drosophila.BicC is necessary for proper Malpighian tubule function.
Title: Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.
Bicaudal C and trailer hitch interact genetically. Mutants of these two genes have shared defects in localization of gurken and other anteriorly-localized mRNAs, as well as altered microtubule organization which may underlie the mRNA localization defects.
Title: Bicaudal C and trailer hitch have similar roles in gurken mRNA localization and cytoskeletal organization.
Bic-C associates with a Trailer Hitch/Me31B complex and is required for efficient Grk secretion.
Title: Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion.
Bic-C regulates expression of specific germline mRNAs by controlling their poly(A)-tail length.
Title: Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber migration	HMP more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in negative regulation of oskar mRNA translation	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bicaudal C

Names: BicC-PA; BicC-PB; BicC-PD; Bicaudal-C; CG4824-PA; CG4824-PB; CG4824-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16042047..16048757

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057517.3 → NP_476865.1 bicaudal C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476865.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24009, Q8IP26

UniProtKB/TrEMBL

E2QCR4

Related

FBpp0080361

Conserved Domains (3) summary

cd09520
Location:805 → 868

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

smart00454
Location:807 → 867

SAM; Sterile alpha motif

cd02394
Location:174 → 240

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_165144.2 → NP_723948.1 bicaudal C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723948.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24009, Q8IP26

UniProtKB/TrEMBL

E2QCR4

Related

FBpp0080362

Conserved Domains (3) summary

cd09520
Location:805 → 868

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

smart00454
Location:807 → 867

SAM; Sterile alpha motif

cd02394
Location:174 → 240

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
NM_165145.1 → NP_723949.1 bicaudal C, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723949.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24009

Related

FBpp0080363, FBtr0080805

Conserved Domains (3) summary

cd09520
Location:685 → 748

SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily

smart00454
Location:687 → 747

SAM; Sterile alpha motif

cd02394
Location:54 → 120

vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...