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    Fak Focal adhesion kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fakprovided by FlyBase
    Official Full Name
    Focal adhesion kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020440
    Locus tag
    Dmel_CG10023
    See related
    AllianceGenome:FB:FBgn0020440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10023; CT28129; dFak; Dfak; DFak; DFAK; Dfak56; DFak56; Dmel\CG10023; DmFAK; fak; FAK; fak56; Fak56; fak56D; Fak56D; FAK65D; pFAK; ptk2
    Summary
    Enables non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of receptor recycling and negative regulation of synaptic assembly at neuromuscular junction. Located in focal adhesion; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including brain; cephalic furrow; egg chamber; follicle cell; and midgut primordium. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fak in Genome Data Viewer
    Location:
    56D5-56D5; 2-89 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19430659..19437259, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15318164..15324764, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene hu li tai shao Neighboring gene transfer RNA:Valine-AAC 2-2 Neighboring gene Calpain-A Neighboring gene ncRNA Neighboring gene Spt5 Neighboring gene Ribosomal protein L11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Fox GL, et al. Proc Natl Acad Sci U S A, 1999 Dec 21. PMID 10611323, Free PMC Article
    2. Mutation of Drosophila focal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission. Ueda A, et al. Eur J Neurosci, 2008 Jun. PMID 18540882, Free PMC Article
    3. An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup and phylogenetic analysis. Zhan LL, et al. J Hered, 2008 Jul-Aug. PMID 18310070
    4. Identification of one intron loss and phylogenetic evolution of Dfak gene in the Drosophila melanogaster species group. Jin S, et al. Genetica, 2005 Nov. PMID 16247694
    5. Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan. Momota R, et al. Int J Biochem Cell Biol, 2013 May. PMID 23454281

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. presynaptic FAK signaling may be disrupted, causing abnormal synaptic growth and transmission in the NF1 genetic
      Title: Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.
    2. Data show that Fak56 is required to restrict larval neuromuscular junctions (NMJ)growth during NMJ development and mediates an extracellular signal through the integrin receptor.
      Title: Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.
    3. An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup.
      Title: An intron loss of Dfak gene in species of the Drosophila melanogaster subgroup and phylogenetic analysis.
    4. Together these findings suggest that modulation of Fak56 function is important for action potential propagation and Ca2+-regulated neuromuscular transmission in vivo.
      Title: Mutation of Drosophila focal adhesion kinase induces bang-sensitive behavior and disrupts glial function, axonal conduction and synaptic transmission.
    5. Fak56 may play a subtle role in the negative regulation of integrin adhesion
      Title: Focal adhesion kinase is not required for integrin function or viability in Drosophila.
    6. Fak56D mutation causes severe disruption of the optic stalk structure. These phenotypes were completely rescued by Fak56D transgene expression in the SG cells but not in photoreceptor cells.
      Title: Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of receptor recycling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in type Ib terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type Is terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    focal adhesion kinase
    Names
    CG10023-PA
    CG10023-PB
    CG10023-PC
    CG10023-PD
    CG10023-PF
    CG10023-PG
    Fak-PA
    Fak-PB
    Fak-PC
    Fak-PD
    Fak-PF
    Fak-PG
    focal adhesion kinase homolog
    protein tyrosine kinase 2
    NP_001137718.1
    NP_001137719.2
    NP_001163207.1
    NP_523793.2
    NP_725891.1
    NP_725892.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19430659..19437259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144247.3 → NP_001137719.2  focal adhesion kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137719.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM0, B8A418, Q0E917
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:949 → 1076
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_166352.3 → NP_725891.1  focal adhesion kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM0, B8A418, Q0E917
      Related
      FBpp0085727
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:949 → 1076
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase

    3. NM_001169736.2 → NP_001163207.1  focal adhesion kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A418, E1JGM8
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:947 → 1074
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase

    4. NM_079069.4 → NP_523793.2  focal adhesion kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523793.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM0, B8A418, Q0E917
      Related
      FBpp0085726
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:949 → 1076
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase

    5. NM_001144246.3 → NP_001137718.1  focal adhesion kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZL9
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:1249 → 1376
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase

    6. NM_166353.3 → NP_725892.1  focal adhesion kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM0, B8A418, Q0E917
      Related
      FBpp0085728
      Conserved Domains (6) summary
      cd05056
      Location:450 → 744
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:24 → 267
      B41; Band 4.1 homologues
      cd13190
      Location:263 → 394
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:152 → 257
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:949 → 1076
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 736
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZL9 B7YZL9
    E1JGM8 E1JGM8
    Q0E917 Q0E917
    Q2TGI0 Q2TGI0
    Q5BIG9 Q5BIG9
    Q9U472 Q9U472
    Q9U531 Q9U531
    Q9U5Y2 Q9U5Y2

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