Ror Ror [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rorprovided by FlyBase
Official Full Name: Rorprovided by FlyBase
Primary source: FLYBASE:FBgn0010407
Locus tag: Dmel_CG4926
See related: AllianceGenome:FB:FBgn0010407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4926; Dmel\CG4926; DmHD-2; Dror; DRor; HD-2; ROR; ROR-alpha; ROR1
Summary: Predicted to enable Wnt-protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in central nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in adult head; central nervous system; and presumptive embryonic/larval peripheral nervous system. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1) and ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10251843..10254686)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10251843..10254686)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

NP_476962.1

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The following sections contain reference sequences that belong to a specific genome build. Explain