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    CG8526 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41208, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG8526provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037759
    Locus tag
    Dmel_CG8526
    See related
    AllianceGenome:FB:FBgn0037759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8526
    Summary
    Predicted to enable asparaginase activity. Predicted to be involved in amino acid metabolic process. Is expressed in several structures, including adult head; central brain primordium; head mesoderm; larval ventral nerve cord; and longitudinal trunk visceral muscle primordium. Orthologous to human ASPG (asparaginase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8526 in Genome Data Viewer
    Location:
    85E9-85E9; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9801280..9803461)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5627002..5629183)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46144 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene F-box protein 11 Neighboring gene antisense RNA:CR44035 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NuRD-independent Mi-2 activity represses ectopic gene expression during neuronal maturation. Aughey GN, et al. EMBO Rep, 2023 Apr 5. PMID 36722816, Free PMC Article
    2. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
    3. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparaginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8526-PA
    CG8526-PB
    NP_001262440.1
    NP_649953.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9801280..9803461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141696.3 → NP_649953.1  uncharacterized protein Dmel_CG8526, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH61
      Related
      FBpp0081620
      Conserved Domains (4) summary
      cd00204
      Location:433 → 588
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00710
      Location:15 → 347
      Asparaginase; Asparaginase
      pfam12796
      Location:442 → 566
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:436 → 467
      ANK; ANK repeat [structural motif]

    2. NM_001275511.1 → NP_001262440.1  uncharacterized protein Dmel_CG8526, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262440.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG17
      Conserved Domains (4) summary
      cd00204
      Location:432 → 587
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00710
      Location:15 → 346
      Asparaginase; Asparaginase
      pfam12796
      Location:441 → 565
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:435 → 466
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG17 A0A0B4KG17
    Q9VH61 Q9VH61

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