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    His4r Histone H4 replacement [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41773, updated on 4-Jan-2025

    Summary

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    Official Symbol
    His4rprovided by FlyBase
    Official Full Name
    Histone H4 replacementprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013981
    Locus tag
    Dmel_CG3379
    See related
    AllianceGenome:FB:FBgn0013981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH52884; CG3379; Dmel\CG3379; FBtr0082962; H4r; His4-88CD; His4R
    Summary
    Enables DNA binding activity. Involved in nucleosome assembly. Located in nuclear chromosome. Part of RCAF complex and nucleosome. Is expressed in adult heart and spermatozoon. Orthologous to several human genes including H4C1 (H4 clustered histone 1); H4C11 (H4 clustered histone 11); and H4C12 (H4 clustered histone 12). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See His4r in Genome Data Viewer
    Location:
    88C9-88C9; 3-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14625755..14626614)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10451477..10452336)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene punt Neighboring gene uncharacterized protein Neighboring gene Cadherin 88C Neighboring gene lethal (3) L1231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster. Crain AT, et al. Genetics, 2022 May 31. PMID 35404465, Free PMC Article
    2. Sex-specific phenotypes of histone H4 point mutants establish dosage compensation as the critical function of H4K16 acetylation in Drosophila. Copur Ö, et al. Proc Natl Acad Sci U S A, 2018 Dec 26. PMID 30530664, Free PMC Article
    3. Hat1 acetylates histone H4 and modulates the transcriptional program in Drosophila embryogenesis. Varga J, et al. Sci Rep, 2019 Nov 29. PMID 31784689, Free PMC Article
    4. Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation. Crain AT, et al. Genes Dev, 2024 Jun 25. PMID 38866557, Free PMC Article
    5. Redesigning the Drosophila histone gene cluster: an improved genetic platform for spatiotemporal manipulation of histone function. Crain AT, et al. Genetics, 2024 Sep 4. PMID 39039029,

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone replacement gene His4r is involved in heat stress induced chromatin rearrangement.
      Title: The histone replacement gene His4r is involved in heat stress induced chromatin rearrangement.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RCAF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone H4 replacement
    Names
    CG3379-PA
    CG3379-PB
    CG3379-PC
    CG3379-PD
    His4r-PA
    His4r-PB
    His4r-PC
    His4r-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14625755..14626614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169592.3 → NP_731927.1  histone H4 replacement, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2W8, P84040, Q4AB71, Q4ABE0, Q6AWN1
      UniProtKB/TrEMBL
      A0A0B4KFZ9
      Related
      FBpp0082421
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional

    2. NM_001275647.1 → NP_001262576.1  histone H4 replacement, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2W8, P84040, Q4AB71, Q4ABE0, Q6AWN1
      UniProtKB/TrEMBL
      A0A0B4KFZ9
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional

    3. NM_079628.4 → NP_524352.1  histone H4 replacement, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2W8, P84040, Q4AB71, Q4ABE0, Q6AWN1
      UniProtKB/TrEMBL
      A0A0B4KFZ9
      Related
      FBpp0082423
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional

    4. NM_169593.3 → NP_731928.1  histone H4 replacement, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2W8, P84040, Q4AB71, Q4ABE0, Q6AWN1
      UniProtKB/TrEMBL
      A0A0B4KFZ9
      Related
      FBpp0082422
      Conserved Domains (1) summary
      PLN00035
      Location:1 → 103
      PLN00035; histone H4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ9 A0A0B4KFZ9
    P84040.2 P84040

    Gene LinkOut

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