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    l(2)k05911 lethal (2) k05911 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)k05911provided by FlyBase
    Official Full Name
    lethal (2) k05911provided by FlyBase
    Primary source
    FLYBASE:FBgn0284244
    Locus tag
    Dmel_CG31728
    See related
    AllianceGenome:FB:FBgn0284244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP36; CG16821; CG31728; cSP36; Dmel\CG31728; SP36
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)k05911 in Genome Data Viewer
    Location:
    34B1-34B2; 2-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13251509..13257426)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13251509..13257426)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 34A Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 20 B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. Garcia-Lopez A, et al. PLoS One, 2008 Feb 13. PMID 18270582, Free PMC Article
    2. Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. Nam HJ, et al. EMBO J, 2012 Mar 7. PMID 22227521, Free PMC Article
    3. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
    4. A genome-wide analysis of immune responses in Drosophila. Irving P, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742098, Free PMC Article
    5. Comparative transcriptome analysis reveals a potential mechanism for host nutritional manipulation after parasitization by Leptopilina boulardi. Zhou S, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2021 Sep. PMID 34120097

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) k05911
    Names
    CG31728-PC
    l(2)k05911-PC
    NP_723797.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13251509..13257426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165031.3 → NP_723797.3  lethal (2) k05911 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723797.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK10
      Conserved Domains (3) summary
      smart00680
      Location:111 → 174
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:399 → 634
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:400 → 637
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8X4 Q8T8X4
    Q9VK10 Q9VK10

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