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    spag4 sperm-associated antigen 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spag4provided by FlyBase
    Official Full Name
    sperm-associated antigen 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032368
    Locus tag
    Dmel_CG6589
    See related
    AllianceGenome:FB:FBgn0032368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6589; Dmel\CG6589; dspag; Dspag4; giac; Spag4
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in double-strand break repair via homologous recombination and spermatogenesis. Colocalizes with spindle microtubule. Is expressed in primary spermatocyte; primary spermatocyte cyst; secondary spermatocyte; spermatid; and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5) and SPAG4 (sperm associated antigen 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spag4 in Genome Data Viewer
    Location:
    32F4-32F4; 2-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11610510..11611772, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11610510..11611772, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44496 Neighboring gene kekkon 2 Neighboring gene Accessory gland-specific peptide 33A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Making the LINC: SUN and KASH protein interactions. Kim DI, et al. Biol Chem, 2015 Apr. PMID 25720065, Free PMC Article
    2. The proximal centriole-like structure maintains nucleus-centriole architecture in sperm. Buglak DB, et al. J Cell Sci, 2024 Sep 1. PMID 39166297, Free PMC Article
    3. Cytoskeletal control of nuclear morphology and chromatin organization. Ramdas NM, et al. J Mol Biol, 2015 Feb 13. PMID 25281900
    4. salto/CG13164 is required for sperm head morphogenesis in Drosophila. Augière C, et al. Mol Biol Cell, 2019 Mar 1. PMID 30601696, Free PMC Article
    5. KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. Starr DA, et al. Bioessays, 2005 Nov. PMID 16237665

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study identified Spag4 (previously named Giacomo) as a component of a centriolar-nuclear attachment pathway in spermatogenesis that also requires the coiled-coil protein Yuri and cytoplasmic dynein-dynactin
      Title: The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm-associated antigen 4
    Names
    CG6589-PB
    giacomo
    spag4-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11610510..11611772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135666.3 → NP_609510.2  sperm-associated antigen 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609510.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HL83, Q9VKG2
      Conserved Domains (1) summary
      pfam07738
      Location:148 → 274
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKG2 Q9VKG2

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