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    Sac1 Sac1 phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38137, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sac1provided by FlyBase
    Official Full Name
    Sac1 phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283500
    Locus tag
    Dmel_CG9128
    See related
    AllianceGenome:FB:FBgn0283500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9128; Dmel\CG9128; dsac1; impatent; l(3)2107; sac1
    Summary
    Enables phosphatidylinositol-4-phosphate phosphatase activity. Involved in several processes, including dorsal closure, amnioserosa morphology change; negative regulation of signal transduction; and nervous system development. Located in axon; neuronal cell body; and sensory dendrite. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; epithelium; and ganglia. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sac1 in Genome Data Viewer
    Location:
    61F4-61F4; 3-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1247817..1250451)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1247817..1250451)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1 Neighboring gene Booster for Crq Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neither insufficiency nor overexpression of sac1 affects the accumulation of Aβ42 in Drosophila expressing Ab42. Han M, et al. Eur Rev Med Pharmacol Sci, 2015. PMID 26004612
    2. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1. Griffiths NW, et al. Mol Biol Cell, 2020 May 15. PMID 32186963, Free PMC Article
    3. The phosphoinositide phosphatase Sac1 is required for midline axon guidance. Lee S, et al. Mol Cells, 2011 Nov. PMID 22042447, Free PMC Article
    4. The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Wei HC, et al. Curr Biol, 2003 Oct 28. PMID 14588244
    5. Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels. Ahaley SS. J Biosci, 2018 Dec. PMID 30541947

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
      Title: Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
    2. The data reveal a novel requirement for Sac1 in promoting microtubule stability and suggest that Rst trafficking occurs in a microtubule- and exocyst-dependent manner.
      Title: The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye.
    3. Here, we present evidence that Sac1 regulates axon guidance in the embryonic CNS of Drosophila
      Title: The phosphoinositide phosphatase Sac1 is required for midline axon guidance.
    4. the first report of a role for Sac1 in the development of a multicellular organism
      Title: The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, amnioserosa morphology change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system HMP PubMed 
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sac1 phosphatase
    Names
    CG9128-PA
    CG9128-PB
    Sac1-PA
    Sac1-PB
    impatent
    suppressor of actin-1
    NP_001189016.1
    NP_612087.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1247817..1250451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202087.1 → NP_001189016.1  Sac1 phosphatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0I6
      UniProtKB/TrEMBL
      M9MRM4
      Conserved Domains (2) summary
      COG5329
      Location:3 → 566
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:62 → 344
      Syja_N; SacI homology domain

    2. NM_138243.4 → NP_612087.1  Sac1 phosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0I6
      UniProtKB/TrEMBL
      M9MRM4
      Related
      FBpp0072546
      Conserved Domains (2) summary
      COG5329
      Location:3 → 566
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:62 → 344
      Syja_N; SacI homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRM4 M9MRM4
    Q9W0I6.1 Q9W0I6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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