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    unc uncoordinated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33093, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uncprovided by FlyBase
    Official Full Name
    uncoordinatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003950
    Locus tag
    Dmel_CG1501
    See related
    AllianceGenome:FB:FBgn0003950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3; 4; 5; CG1501; Dmel\CG1501; l(1)19Ef; l(1)6-3-212; lLV7; Unc; UNC; W5
    Summary
    Involved in cilium assembly; locomotory behavior; and sensory perception of sound. Located in several cellular components, including ciliary cap; microtubule organizing center; and ring centriole. Is expressed in chordotonal organ precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc in Genome Data Viewer
    Location:
    19F1-19F1; 1-65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21111414..21116914, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20982441..20987941, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stargazin-like protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44374 Neighboring gene uncharacterized protein Neighboring gene lipid droplet defective

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique properties of Drosophila spermatocyte primary cilia. Riparbelli MG, et al. Biol Open, 2013. PMID 24244850, Free PMC Article
    2. Molecular studies on interspersed repetitive and unique sequences in the region of the complementation group uncoordinated on the X chromosome of Drosophila melanogaster. Healy MJ, et al. Mol Gen Genet, 1988 Jul. PMID 2851711
    3. Transcriptional analyses of the uncoordinated region of Drosophila melanogaster. Healy MJ, et al. Genome, 1990 Dec. PMID 1707845
    4. The "transition zone" of the cilium-like regions in the Drosophila spermatocytes and the role of the C-tubule in axoneme assembly. Gottardo M, et al. Exp Cell Res, 2018 Oct 1. PMID 30130520
    5. The cilium-like region of the Drosophila spermatocyte: an emerging flagellum? Gottardo M, et al. J Cell Sci, 2013 Dec 1. PMID 24105264

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary cap IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ring centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncoordinated
    Names
    CG1501-PA
    CG1501-PB
    section 3
    section 4
    section 5
    unc-PA
    unc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21111414..21116914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298583.1 → NP_001285512.1  uncoordinated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5XM86, Q8MST7, Q9VRF2
      Conserved Domains (1) summary
      pfam16045
      Location:225 → 252
      LisH_2; LisH

    2. NM_134591.2 → NP_608435.2  uncoordinated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608435.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5XM86, Q8MST7, Q9VRF2
      Conserved Domains (1) summary
      pfam16045
      Location:225 → 252
      LisH_2; LisH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MST7 Q8MST7
    Q9VRF2 Q9VRF2

    Gene LinkOut

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