U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DIP-alpha Dpr-interacting protein alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31322, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DIP-alphaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052791
    Locus tag
    Dmel_CG32791
    See related
    AllianceGenome:FB:FBgn0052791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    32791; CG13019; CG13020; CG32791; Dip-alpha; DIPalpha; Dmel\CG32791
    Summary
    Involved in synapse organization. Located in neuron projection membrane. Is expressed in ganglia; larval ventral midline glial cell; medulla; optic lobe intrinsic neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DIP-alpha in Genome Data Viewer
    Location:
    3D4-3D6; 1-3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3507245..3571649, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3401278..3465682, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene Growth arrest specific protein 8 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR34335 Neighboring gene pickpocket 8 Neighboring gene Allatostatin A receptor 1 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 7 Neighboring gene Poly(ADP-ribose) glycohydrolase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity. Ashley J, et al. Elife, 2019 Feb 4. PMID 30714906, Free PMC Article
    2. hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit. Wang Y, et al. Commun Biol, 2024 Apr 27. PMID 38678127, Free PMC Article
    3. Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons in Drosophila. Aponte-Santiago NA, et al. J Neurosci, 2020 Aug 12. PMID 32631939, Free PMC Article
    4. Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila. Wang Y, et al. Nat Commun, 2023 Jul 24. PMID 37488133, Free PMC Article
    5. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hkb is required for DIP-alpha expression and target recognition in the Drosophila neuromuscular circuit.
      Title: hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit.
    2. We propose a model whereby DIP-alpha and Dpr10 on opposing synaptic partners interact with each other to generate proper motor neuron connectivity.
      Title: Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity.
    3. different leg Motor neurons depend on the DIP-alpha and Dpr10 interaction to varying degrees that correlate with the morphological complexity of the Motor neurons and their muscle targets.
      Title: Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.
    4. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
      Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Dpr-interacting protein alpha
    Names
    CG32791-PA
    CG32791-PB
    CG32791-PC
    DIP-alpha-PA
    DIP-alpha-PB
    DIP-alpha-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3507245..3571649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272289.1 → NP_001259218.1  Dpr-interacting protein alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4R3
      Conserved Domains (4) summary
      smart00408
      Location:159 → 228
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:49 → 129
      IG_like; Immunoglobulin like
      pfam07679
      Location:144 → 240
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:244 → 337
      Ig; Immunoglobulin domain

    2. NM_001272288.2 → NP_001259217.1  Dpr-interacting protein alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGE1
      Conserved Domains (3) summary
      smart00408
      Location:37 → 106
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:22 → 118
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:122 → 215
      Ig; Immunoglobulin domain

    3. NM_166976.3 → NP_726871.1  Dpr-interacting protein alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726871.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4R3
      Related
      FBpp0070563
      Conserved Domains (4) summary
      smart00408
      Location:159 → 228
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:49 → 129
      IG_like; Immunoglobulin like
      pfam07679
      Location:144 → 240
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:244 → 337
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGE1 M9PGE1
    Q9W4R3 Q9W4R3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous