Ca-alpha1D Ca[2+]-channel protein alpha[[1]] subunit D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ca-alpha1Dprovided by FlyBase
Official Full Name: Ca[2+]-channel protein alpha[[1]] subunit Dprovided by FlyBase
Primary source: FLYBASE:FBgn0001991
Locus tag: Dmel_CG4894
See related: AllianceGenome:FB:FBgn0001991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A1D; alpha1; alpha1D; BG:DS02795.1; Ca-a1D; Ca-alpha1; ca-alpha1d; ca-alpha1D; Ca-Alpha1D; Ca-alphaID; Ca-alpha[[1]]D; Ca-_1D; Ca1D; Caalpha1D; cad; CAD; caID; Ca_alpha1D; CG4894; D-type Ca[2+]; DmCa1alpha1; dmca1D; Dmca1D; DmCa1D; Dmel\CG4894; DroCa1; l(2)35Fa; l35Fa
Summary: Enables voltage-gated calcium channel activity. Involved in several processes, including detection of temperature stimulus involved in sensory perception of pain; epithelial fluid transport; and neuron remodeling. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in adult head; organism; presumptive embryonic/larval nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Brugada syndrome 3; Timothy syndrome; eye disease (multiple); hypokalemic periodic paralysis; and muscle tissue disease (multiple). Orthologous to several human genes including CACNA1C (calcium voltage-gated channel subunit alpha1 C); CACNA1F (calcium voltage-gated channel subunit alpha1 F); and CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35E5-35E6; 2-51 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16165831..16190540)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16165831..16190540)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
Title: Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
Stac protein regulates release of neuropeptides.
Title: Stac protein regulates release of neuropeptides.
Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
Title: Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum.
maximum intraburst firing rates require axonal calcium influx through Dmca1D channels, likely to enhance sodium channel de-inactivation via a fast afterhyperpolarization through BK channel activation
Title: Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion.
The Ca(2+) current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca(2+) channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.
Title: The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles.
cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications
Title: Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.
The study indicated that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions.
Title: Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions.
This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones.
Title: Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial fluid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial fluid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of voltage-gated calcium channel complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Ca[2+]-channel protein alpha[[1]] subunit D

Names: CG4894-PF; CG4894-PG; CG4894-PH; CG4894-PI; CG4894-PJ; CG4894-PK; CG4894-PL; CG4894-PM; CG4894-PN; CG4894-PO; Ca-alpha1D-PF; Ca-alpha1D-PG; Ca-alpha1D-PH; Ca-alpha1D-PI; Ca-alpha1D-PJ; Ca-alpha1D-PK; Ca-alpha1D-PL; Ca-alpha1D-PM; Ca-alpha1D-PN; Ca-alpha1D-PO; Ca2+-channel protein alpha1 subunit D; Ca[2+]-channel alpha1 subunit; alpha-1 subunit Ca2[+] channel type D; calcium channel alpha-1 subunit; drosophila melanogaster calcium channel alpha[[1]] subunit DHP-sensitive

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16165831..16190540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273556.1 → NP_001260485.1 Ca[2+]-channel protein alpha[[1]] subunit D, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260485.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

UniProtKB/TrEMBL

M9PDI5

Conserved Domains (4) summary

pfam00520
Location:1223 → 1480

Ion_trans; Ion transport protein

pfam08763
Location:1553 → 1625

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1843 → 1924

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1488 → 1551

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001273555.1 → NP_001260484.1 Ca[2+]-channel protein alpha[[1]] subunit D, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260484.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

UniProtKB/TrEMBL

M9PD04

Conserved Domains (4) summary

pfam00520
Location:1190 → 1447

Ion_trans; Ion transport protein

pfam08763
Location:1520 → 1592

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1810 → 1891

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1455 → 1518

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001273552.1 → NP_001260481.1 Ca[2+]-channel protein alpha[[1]] subunit D, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260481.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

UniProtKB/TrEMBL

M9PD78

Conserved Domains (4) summary

pfam00520
Location:1187 → 1444

Ion_trans; Ion transport protein

pfam08763
Location:1517 → 1589

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1807 → 1888

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1452 → 1515

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001273553.1 → NP_001260482.1 Ca[2+]-channel protein alpha[[1]] subunit D, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260482.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFZ4

Conserved Domains (3) summary

pfam00520
Location:1187 → 1444

Ion_trans; Ion transport protein

pfam08763
Location:1517 → 1589

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1452 → 1515

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001273554.1 → NP_001260483.1 Ca[2+]-channel protein alpha[[1]] subunit D, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260483.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

UniProtKB/TrEMBL

M9PBC0

Conserved Domains (4) summary

pfam00520
Location:1187 → 1444

Ion_trans; Ion transport protein

pfam08763
Location:1517 → 1589

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1807 → 1888

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1452 → 1515

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_134429.3 → NP_602305.2 Ca[2+]-channel protein alpha[[1]] subunit D, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

Conserved Domains (3) summary

pfam00520
Location:767 → 1042

Ion_trans; Ion transport protein

pfam08763
Location:2163 → 2235

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:2099 → 2152

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_165147.2 → NP_723953.2 Ca[2+]-channel protein alpha[[1]] subunit D, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

Conserved Domains (3) summary

pfam00520
Location:767 → 1042

Ion_trans; Ion transport protein

pfam08763
Location:2163 → 2235

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:2099 → 2152

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_080365.3 → NP_525104.3 Ca[2+]-channel protein alpha[[1]] subunit D, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

Conserved Domains (3) summary

pfam00520
Location:767 → 1042

Ion_trans; Ion transport protein

pfam08763
Location:2166 → 2238

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:2102 → 2155

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001273551.1 → NP_001260480.2 Ca[2+]-channel protein alpha[[1]] subunit D, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

UniProtKB/TrEMBL

M9PDI1

Conserved Domains (3) summary

pfam00520
Location:799 → 1074

Ion_trans; Ion transport protein

pfam08763
Location:2192 → 2267

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:2129 → 2182

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_165146.2 → NP_723952.2 Ca[2+]-channel protein alpha[[1]] subunit D, isoform M [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7

Conserved Domains (3) summary

pfam00520
Location:767 → 1042

Ion_trans; Ion transport protein

pfam08763
Location:2199 → 2271

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:2135 → 2188

GPHH; Voltage-dependent L-type calcium channel, IQ-associated