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    Irk1 Inwardly rectifying potassium channel 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irk1provided by FlyBase
    Official Full Name
    Inwardly rectifying potassium channel 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0265042
    Locus tag
    Dmel_CG44159
    See related
    AllianceGenome:FB:FBgn0265042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13836; CG44159; CG6747; Dir; DIR; dIRK; dKirI; Dmel\CG44159; Dm_3R:100326; Dm_3R:100349; ir; Ir; irk1; Kir1
    Old locus tag
    Dmel_CG13836; Dmel_CG6747
    Summary
    Enables inward rectifier potassium channel activity. Involved in several processes, including locomotor rhythm; potassium ion transport; and wing disc development. Located in membrane. Is expressed in several structures, including adult head; embryonic/larval corpus cardiacum; epithelial tube; ganglia; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including EAST syndrome; autosomal recessive nonsyndromic deafness 4; glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Orthologous to several human genes including KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) and KCNJ9 (potassium inwardly rectifying channel subfamily J member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Irk1 in Genome Data Viewer
    Location:
    94E3-94E4; 3-78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23168317..23185642)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18994039..19011364)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase AC39 subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cap-n-collar Neighboring gene fuzzy onions Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Dir: a putative potassium inward rectifying channel in Drosophila. MacLean SJ, et al. Mech Dev, 2002 Aug. PMID 12128223
    2. Role of inward rectifier potassium channels in salivary gland function and sugar feeding of the fruit fly, Drosophila melanogaster. Swale DR, et al. Pestic Biochem Physiol, 2017 Sep. PMID 28911739
    3. Inwardly Rectifying Potassium (Kir) Channels Represent a Critical Ion Conductance Pathway in the Nervous Systems of Insects. Chen R, et al. Sci Rep, 2018 Jan 25. PMID 29371678, Free PMC Article
    4. Neuronal excitability as a regulator of circuit remodeling. Mayseless O, et al. Curr Biol, 2023 Mar 13. PMID 36758544, Free PMC Article
    5. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Wu Y, et al. Am J Physiol Regul Integr Comp Physiol, 2015 Oct. PMID 26224687, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Irk1 and Irk2 play redundant roles in transepithelial ion transport in the Drosophila melanogaster renal tubule and are additive to Na(+)/K(+)-ATPase-dependent pathways
      Title: Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function.
    2. Drosophila inward rectifier (Dir) is the first putative inward rectifier to be studied in Drosophila.
      Title: Characterization of Dir: a putative potassium inward rectifying channel in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inwardly rectifying potassium channel 1
    Names
    CG44159-PB
    CG44159-PC
    CG44159-PD
    CG44159-PE
    CG44159-PF
    CG44159-PG
    CG44159-PH
    Ir
    Irk1-PB
    Irk1-PC
    Irk1-PD
    Irk1-PE
    Irk1-PF
    Irk1-PG
    Irk1-PH
    drosophila inward rectifier
    inwardly rectifying potassium channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23168317..23185642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275933.1 → NP_001262862.1  inwardly rectifying potassium channel 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH86, C9QPA7
      Conserved Domains (1) summary
      pfam01007
      Location:145 → 477
      IRK; Inward rectifier potassium channel

    2. NM_001275932.1 → NP_001262861.1  inwardly rectifying potassium channel 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH86, C9QPA7
      Conserved Domains (1) summary
      pfam01007
      Location:145 → 477
      IRK; Inward rectifier potassium channel

    3. NM_001202341.1 → NP_001189270.1  inwardly rectifying potassium channel 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCZ2, C9QPA7
      Conserved Domains (1) summary
      pfam01007
      Location:33 → 365
      IRK; Inward rectifier potassium channel

    4. NM_001104414.2 → NP_001097884.1  inwardly rectifying potassium channel 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR87, C9QPA7
      Conserved Domains (1) summary
      pfam01007
      Location:48 → 380
      IRK; Inward rectifier potassium channel

    5. NM_001275934.1 → NP_001262863.1  inwardly rectifying potassium channel 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPA7, E1JIU2
      Conserved Domains (1) summary
      pfam01007
      Location:19 → 351
      IRK; Inward rectifier potassium channel

    6. NM_001170226.1 → NP_001163697.1  inwardly rectifying potassium channel 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPA7, E1JIU2
      Conserved Domains (1) summary
      pfam01007
      Location:19 → 351
      IRK; Inward rectifier potassium channel

    7. NM_142874.3 → NP_651131.2  inwardly rectifying potassium channel 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPA7, Q9VCQ0
      Related
      FBpp0307578
      Conserved Domains (1) summary
      pfam01007
      Location:25 → 357
      IRK; Inward rectifier potassium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCZ2 A0A0B4JCZ2
    A0A0B4KH86 A0A0B4KH86
    A8JR87 A8JR87
    E1JIU2 E1JIU2
    Q95UP7 Q95UP7
    Q9VCQ0 Q9VCQ0

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