alphaTub84B alpha-Tubulin at 84B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alphaTub84Bprovided by FlyBase
Official Full Name: alpha-Tubulin at 84Bprovided by FlyBase
Primary source: FLYBASE:FBgn0003884
Locus tag: Dmel_CG1913
See related: AllianceGenome:FB:FBgn0003884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1t; a-tub84B; a1t; ALPHA 84C; alpha-tub; alpha-Tub; alpha-tub84B; alpha-Tub84B; alpha-tubulin; alpha-tubulin 84B; Alpha-Tubulin84B; alpha1; alpha1-tubulin; alpha1t; alpha1tub; alpha1tub84B; alpha84B; alphaT; alphat-1; alphatub; alphaTub; alphaTUB; alphaTub1; alphaTub84; alphatub84b; alphatub84B; alphaTUB84B; AlphaTub84B; alphaTubulin; anon-EST:Liang-1.59; anon-EST:Liang-2.30; aTub84B; BEST:LD32507; CG1913; chr3R:2914276..2914416; clone 1.59; clone 2.30; DM1alpha; Dmel\CG1913; DTA1; FBgn0003884; l(3)84Bd; l(3)g3; ms(3)nc33; nc33; T; Talpha1; TBA1_DROME; tub; Tub; Tub 84B; Tub1C; Tub84B; tubA84B; Tuba84B; tubalpha1; Tubalpha1; tubulin; Tubulin84B
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in lysosome localization. Located in astral microtubule; centrosome; and perinuclear region of cytoplasm. Is expressed in several structures, including appendage; central nervous system; germline cell; gonad; and imaginal disc. Human ortholog(s) of this gene implicated in keratoconus; lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to several human genes including TUBA3C (tubulin alpha 3c) and TUBA3D (tubulin alpha 3d). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 84B2-84B2; 3-48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7086599..7088839)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2912321..2914561)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyto-architecture constrains the spread of photoactivated tubulin in the syncytial Drosophila embryo.
Title: Cyto-architecture constrains the spread of photoactivated tubulin in the syncytial Drosophila embryo.
To resolve how microtubule acetylation might affect neuronal morphogenesis, we mutated endogenous alpha-tubulin in vivo using a new Drosophila strain that facilitates the rapid knock-in of designer alphaTub84B alleles (the predominant alpha-tubulin-encoding gene in flies)...Our studies point to an unappreciated role for a-tubulin K40 and acetylation in dendrite morphogenesis.
Title: Effects of mutating α-tubulin lysine 40 on sensory dendrite development.
human RITA, binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly
Title: Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

kalpha1 (e-PCR)
- UniSTS:205590

D1S3688 (e-PCR)
- UniSTS:474266

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lysosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in astral microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: alpha-Tubulin at 84B

Names: CG1913-PA; Tubulin-alpha1; alpha tubulin; alpha tubulin 84B; alpha-Tubulin; alpha-Tubulin 84B; alpha-tubulin 1; alpha-tubulin84B; alpha1 tubulin; alpha1-tubulin; alphaT; alphaTub84B-PA; alphaTubulin 84B; alphaTubulin84B; alpha[[1]] tubulin; alpha[[1]]-tubulin; alphatubulin; tubulin; tubulin 1 alpha-chain; tubulin 1alpha; tubulin alpha1; tubulin alpha1 promoter; tubulin(alpha1); tubulin1alpha; tubulin84B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

7086599..7088839

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057424.4 → NP_476772.1 alpha-Tubulin at 84B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476772.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P06603, Q9VI59

UniProtKB/TrEMBL

K7WKV5

Related

FBpp0081153

Conserved Domains (1) summary

PTZ00335
Location:1 → 439

PTZ00335; tubulin alpha chain; Provisional