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    NPFR Neuropeptide F receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40754, updated on 17-Dec-2024

    Summary

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    Official Symbol
    NPFRprovided by FlyBase
    Official Full Name
    Neuropeptide F receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037408
    Locus tag
    Dmel_CG1147
    See related
    AllianceGenome:FB:FBgn0037408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0131005.3; anon-WO0131005.5; CG1147; Dmel\CG1147; DmNPFR1; dNPFR1; Drm-NPFR; NPF R; NPF receptor; NPF-R; NPF-R1; npfr; NPFr; NPFR-1; npfr1; NPFR1; RE18294p
    Summary
    Enables neuropeptide F receptor activity and neuropeptide binding activity. Involved in several processes, including larval feeding behavior; neuropeptide signaling pathway; and response to odorant. Located in plasma membrane. Is expressed in several structures, including crop; embryonic central brain; ganglia; gut section; and larval midline neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See NPFR in Genome Data Viewer
    Location:
    83D5-83E1; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6187315..6195403)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2013037..2021125)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Osiris 1 Neighboring gene pseudo Neighboring gene Osiris 24 Neighboring gene Osiris 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of sleep by neuropeptide Y-like system in Drosophila melanogaster. He C, et al. PLoS One, 2013. PMID 24040211, Free PMC Article
    2. Graded encoding of food odor value in the Drosophila brain. Beshel J, et al. J Neurosci, 2013 Oct 2. PMID 24089477, Free PMC Article
    3. Developmental Ethanol Exposure Causes Reduced Feeding and Reveals a Critical Role for Neuropeptide F in Survival. Guevara A, et al. Front Physiol, 2018. PMID 29623043, Free PMC Article
    4. Co-regulation of cold-resistant food acquisition by insulin- and neuropeptide Y-like systems in Drosophila melanogaster. Lingo PR, et al. Neuroscience, 2007 Aug 24. PMID 17658221, Free PMC Article
    5. Dissection of the Drosophila neuropeptide F circuit using a high-throughput two-choice assay. Shao L, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28874527, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A New Role for Neuropeptide F Signaling in Controlling Developmental Timing and Body Size in Drosophila melanogaster.
      Title: A New Role for Neuropeptide F Signaling in Controlling Developmental Timing and Body Size in Drosophila melanogaster.
    2. Male-specific sex-dependent regulatory function of sleep is controlled by NPF and NPFR1 expression in the brain.
      Title: Regulation of sleep by neuropeptide Y-like system in Drosophila melanogaster.
    3. Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila.
      Title: Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila.
    4. in males, mating increased, whereas sexual deprivation reduced, NPF levels; propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly
      Title: Sexual deprivation increases ethanol intake in Drosophila.
    5. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior.
      Title: Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search.
    6. NPFR requires an Arg residue at position 4 from the amidated C-terminus for ativation by short NPFs
      Title: Characterization of the short neuropeptide F receptor from Drosophila melanogaster.
    7. expressed in CNS and midgut; a functional receptor for Drosophila neuropeptide F (DmNPF)
      Title: Characterization of a functional neuropeptide F receptor from Drosophila melanogaster.
    8. Results identify a Drosophila signaling system, comprising neurons expressing neuropeptide F and its receptor, NPFR1, that acutely mediates sensitivity to ethanol sedation.
      Title: Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide F receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multi-organism reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to odorant IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tachykinin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuropeptide F receptor
    Names
    CG1147-PA
    CG1147-PB
    CG1147-PC
    CG1147-PD
    NPF-receptor
    NPFR-PA
    NPFR-PB
    NPFR-PC
    NPFR-PD
    dNPF receptor
    neuropeptide F receptor 1
    neuropeptide F receptor-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6187315..6195403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079521.4 → NP_524245.3  neuropeptide F receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524245.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2CFP0, D2CFP1, D2CFP2, D2CFP3, D2CFP4, Q7KFF8, Q8SZ35, Q967T7, Q9VNM1
      Related
      FBpp0078239
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    2. NM_001260018.2 → NP_001246947.1  neuropeptide F receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K601
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    3. NM_001260017.2 → NP_001246946.1  neuropeptide F receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6K3
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor

    4. NM_001260016.2 → NP_001246945.1  neuropeptide F receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6A5
      Conserved Domains (2) summary
      pfam00001
      Location:103 → 373
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 195
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K601 A0A0B4K601
    A0A0B4K6A5 A0A0B4K6A5
    A0A0B4K6K3 A0A0B4K6K3
    Q9VNM1.3 Q9VNM1

    Gene LinkOut

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