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    Sb Stubble [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sbprovided by FlyBase
    Official Full Name
    Stubbleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003319
    Locus tag
    Dmel_CG4316
    See related
    AllianceGenome:FB:FBgn0003319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP56; CG4316; cSP56; Dmel\CG4316; Sb-sbd; sbd; SP56; st-sb
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in actin filament bundle assembly and wing disc development. Predicted to be located in plasma membrane. Is expressed in imaginal disc; leg; wing; wing anterior compartment; and wing pouch. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase); TMPRSS13 (transmembrane serine protease 13); and TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    89B4-89B6; 3-58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16116161..16145284)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11941883..11971006)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin heavy chain-like Neighboring gene sex-specific enzyme 2 Neighboring gene Akt kinase Neighboring gene MICOS subunit 26/27 Neighboring gene uncharacterized protein Neighboring gene 48 related 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. Hooper JD, et al. J Biol Chem, 2001 Jan 12. PMID 11060317
    2. The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Appel LF, et al. Proc Natl Acad Sci U S A, 1993 Jun 1. PMID 7685111, Free PMC Article
    3. Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism. Condic ML, et al. Development, 1991 Jan. PMID 2015798
    4. Persistence of a mutant gene in Drosophila populations of different genetic backgrounds. Chung YJ. Genetics, 1967 Dec. PMID 17248400, Free PMC Article
    5. Evidence for intrinsic differences in the formation of chromatin domains in Drosophila melanogaster. Bishop CP. Genetics, 1992 Dec. PMID 1459427, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Helps coordinate proteolytic modification of extracellular matrix attachments with cytoskeletal changes in both legs and bristles.
      Title: Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis.
    2. RhoA and Sb-sbd act in a common pathway during leg morphogenesis
      Title: Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stubble
    Names
    CG4316-PA
    CG4316-PB
    Sb-PA
    Sb-PB
    Stubble-stubbloid
    stubbloid
    NP_001287355.1
    NP_476709.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16116161..16145284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300426.1 → NP_001287355.1  stubble, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05319, Q8MRH5, Q9VEY6
      UniProtKB/TrEMBL
      A0A0B4LH73
      Conserved Domains (2) summary
      smart00020
      Location:543 → 782
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:544 → 785
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_057361.4 → NP_476709.1  stubble, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476709.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05319, Q8MRH5, Q9VEY6
      UniProtKB/TrEMBL
      A0A0B4LH73
      Related
      FBpp0082704
      Conserved Domains (2) summary
      smart00020
      Location:543 → 782
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:544 → 785
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH73 A0A0B4LH73
    Q05319.2 Q05319

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