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    CG4975 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4975provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034266
    Locus tag
    Dmel_CG4975
    See related
    AllianceGenome:FB:FBgn0034266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Atxn10; Dmel\CG4975
    Summary
    Predicted to be involved in neuron projection development. Located in cytosol. Is expressed in larval muscle system and larval somatic muscle cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 10. Orthologous to human ATXN10 (ataxin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4975 in Genome Data Viewer
    Location:
    54E2-54E4; 2-84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17726914..17732987)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13614419..13620492)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dachs ligand with SH3s Neighboring gene Sorting nexin 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hyccin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269
    2. Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells. Vieillard J, et al. J Cell Biol, 2016 Sep 26. PMID 27646273, Free PMC Article
    3. A presynaptic endosomal trafficking pathway controls synaptic growth signaling. Rodal AA, et al. J Cell Biol, 2011 Apr 4. PMID 21464232, Free PMC Article
    4. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
    5. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Rossi F, et al. Open Biol, 2017 Aug. PMID 28855394, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4975-PC
    CG4975-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17726914..17732987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144221.3 → NP_001137693.2  uncharacterized protein Dmel_CG4975, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137693.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ4, G4LTX3
      Conserved Domains (1) summary
      pfam09759
      Location:322 → 408
      Atx10homo_assoc; Spinocerebellar ataxia type 10 protein domain

    2. NM_001144222.2 → NP_001137694.1  uncharacterized protein Dmel_CG4975, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZJ4, G4LTX3
      Conserved Domains (1) summary
      pfam09759
      Location:322 → 408
      Atx10homo_assoc; Spinocerebellar ataxia type 10 protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZJ4 B7YZJ4

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