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    CG43693 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43693provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263776
    Locus tag
    Dmel_CG43693
    See related
    AllianceGenome:FB:FBgn0263776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34239; CG6327; Dmel\CG43693
    Old locus tag
    Dmel_CG34239; Dmel_CG6327
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in vacuolar membrane. Is expressed in several structures, including adult head; amnioserosa; amnioserosa primordium; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43693 in Genome Data Viewer
    Location:
    68A2-68A3; 3-34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11036358..11051371, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11029458..11044471, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44547 Neighboring gene long non-coding RNA:CR45119 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Ng FS, et al. Front Mol Neurosci, 2016. PMID 28066175, Free PMC Article
    2. A single-cell atlas of the developing Drosophila ovary identifies follicle stem cell progenitors. Slaidina M, et al. Genes Dev, 2020 Feb 1. PMID 31919193, Free PMC Article
    3. Comparison of larval and adult Drosophila astrocytes reveals stage-specific gene expression profiles. Huang Y, et al. G3 (Bethesda), 2015 Feb 4. PMID 25653313, Free PMC Article
    4. Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. Bina S, et al. EMBO Rep, 2010 Mar. PMID 20168330, Free PMC Article
    5. Genes underlying species differences in cuticular hydrocarbon production between Drosophila melanogaster and D. simulans. Ward HKE, et al. Genome, 2021 Feb. PMID 33211537

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43693-PA
    CG43693-PB
    CG43693-PC
    CG43693-PD
    CG43693-PE
    CG43693-PF
    CG43693-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11036358..11051371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206319.3 → NP_996041.1  uncharacterized protein Dmel_CG43693, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996041.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUE9, Q8T3P1
      Conserved Domains (2) summary
      COG0814
      Location:71 → 479
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:76 → 480
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001274765.1 → NP_001261694.1  uncharacterized protein Dmel_CG43693, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEU1, Q8T3P1
      Conserved Domains (2) summary
      COG0814
      Location:153 → 561
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:158 → 562
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001274764.1 → NP_001261693.1  uncharacterized protein Dmel_CG43693, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC57, Q8T3P1
      Conserved Domains (2) summary
      COG0814
      Location:80 → 488
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:85 → 489
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001274763.1 → NP_001261692.1  uncharacterized protein Dmel_CG43693, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI01, Q8T3P1
      Conserved Domains (2) summary
      COG0814
      Location:36 → 444
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:41 → 445
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_168431.3 → NP_729648.1  uncharacterized protein Dmel_CG43693, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P1, Q9VTD6
      Related
      FBpp0302704
      Conserved Domains (2) summary
      COG0814
      Location:83 → 491
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:88 → 492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. NM_140167.3 → NP_648424.1  uncharacterized protein Dmel_CG43693, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P1, Q9VTD6
      Related
      FBpp0302703
      Conserved Domains (2) summary
      COG0814
      Location:83 → 491
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:88 → 492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. NM_168432.2 → NP_729649.2  uncharacterized protein Dmel_CG43693, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729649.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQF2, Q8T3P1
      Related
      FBpp0302705
      Conserved Domains (2) summary
      COG0814
      Location:63 → 471
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:68 → 472
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC57 M9PC57
    M9PEU1 M9PEU1
    M9PI01 M9PI01
    Q7KUE9 Q7KUE9
    Q8IQF2 Q8IQF2
    Q8T3P1 Q8T3P1
    Q9VTD6 Q9VTD6

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