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    strat stratum [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stratprovided by FlyBase
    Official Full Name
    stratumprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032020
    Locus tag
    Dmel_CG7787
    See related
    AllianceGenome:FB:FBgn0032020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE45155; CG7787; Dmel\CG7787; Strat
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in polarized secretion of basement membrane proteins in epithelium. Located in basal cortex. Orthologous to human RABIF (RAB interacting factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See strat in Genome Data Viewer
    Location:
    29A4-29A4; 2-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8320328..8321285)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8320328..8321285)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitoshell Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene without maturity

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors. Ochi Y, et al. Mol Biol Cell, 2022 Sep 1. PMID 35767331, Free PMC Article
    2. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells. Devergne O, et al. Cell Rep, 2017 Feb 21. PMID 28228250, Free PMC Article
    3. The Clathrin adaptor AP-1 and Stratum act in parallel pathways to control Notch activation in Drosophila sensory organ precursors cells. Bellec K, et al. Development, 2021 Jan 10. PMID 33298463, Free PMC Article
    4. Stratum recruits Rab8 at Golgi exit sites to regulate the basolateral sorting of Notch and Sanpodo. Bellec K, et al. Development, 2018 Jul 2. PMID 29967125
    5. Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. Le Bras S, et al. J Cell Sci, 2012 Oct 15. PMID 22825875

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in polarized secretion of basement membrane proteins in epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stratum
    Names
    CG7787-PA
    strat-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8320328..8321285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135365.3 → NP_609209.2  stratum [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609209.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGQ8, Q9VLP3
      UniProtKB/TrEMBL
      A0A1B2AJA9
      Related
      FBpp0079221
      Conserved Domains (1) summary
      pfam04421
      Location:34 → 119
      Mss4; Mss4 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLP3.2 Q9VLP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools