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    shop shopper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32878, updated on 17-Dec-2024

    Summary

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    Official Symbol
    shopprovided by FlyBase
    Official Full Name
    shopperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030966
    Locus tag
    Dmel_CG7280
    See related
    AllianceGenome:FB:FBgn0030966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7280; Dmel\CG7280; Suox
    Summary
    Enables sulfite oxidase activity. Involved in intracellular sulfate ion homeostasis. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic large intestine; embryonic/larval ensheathing glial cell; and gut section. Used to study isolated sulfite oxidase deficiency. Human ortholog(s) of this gene implicated in inherited metabolic disorder and isolated sulfite oxidase deficiency. Orthologous to human SUOX (sulfite oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shop in Genome Data Viewer
    Location:
    17E1-17E1; 1-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18846389..18848566, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18740422..18742599, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene PDGF- and VEGF-related factor 1 Neighboring gene hat-trick Neighboring gene uncharacterized protein Neighboring gene Ubiquitin specific protease 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Otto N, et al. Nat Commun, 2018 Aug 29. PMID 30158546, Free PMC Article
    2. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
    3. Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila. Wang H, et al. Development, 2016 Feb 1. PMID 26718004, Free PMC Article
    4. Neuron-glia interaction in the Drosophila nervous system. Bittern J, et al. Dev Neurobiol, 2021 Jul. PMID 32096904
    5. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfite oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfite oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular sulfate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shopper
    Names
    CG7280-PA
    shop-PA
    sulfite oxidase
    NP_573331.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18846389..18848566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133103.3 → NP_573331.1  shopper [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWP4
      Related
      FBpp0074426
      Conserved Domains (3) summary
      PLN00177
      Location:199 → 572
      PLN00177; sulfite oxidase; Provisional
      cd02111
      Location:211 → 572
      eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
      pfam00173
      Location:110 → 185
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWP4.1 Q9VWP4

    Gene LinkOut

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