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    sgll sugarlethal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40925, updated on 27-Dec-2024

    Summary

    Official Symbol
    sgllprovided by FlyBase
    Official Full Name
    sugarlethalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051472
    Locus tag
    Dmel_CG31472
    See related
    AllianceGenome:FB:FBgn0051472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2649; CG31472; Dmel\CG31472; dPNPO; Sgll
    Summary
    Enables pyridoxamine phosphate oxidase activity. Involved in pyridoxal phosphate biosynthetic process and response to sucrose. Predicted to be located in mitochondrial intermembrane space. Is expressed in adult head and organism. Used to study pyridoxamine 5'-phosphate oxidase deficiency. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sgll in Genome Data Viewer
    Location:
    84E1-84E1; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7810532..7811912)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3636254..3637634)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables FMN binding  
    enables pyridoxamine phosphate oxidase activity  
    enables pyridoxamine phosphate oxidase activity  
    enables pyridoxamine phosphate oxidase activity PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space  

    General protein information

    Preferred Names
    sugarlethal
    Names
    CG31472-PA
    CG31472-PB
    pyridoxine 5'-phosphate oxidase
    sgll-PA
    sgll-PB
    NP_731186.2
    NP_731187.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7810532..7811912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169195.4 → NP_731187.1  sugarlethal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSW3
      Related
      FBpp0081245
      Conserved Domains (3) summary
      TIGR00558
      Location:33 → 237
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:50 → 126
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:182 → 237
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region
    2. NM_169194.4 → NP_731186.2  sugarlethal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731186.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS89, Q9VHZ5
      Related
      FBpp0081244
      Conserved Domains (3) summary
      TIGR00558
      Location:42 → 246
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:59 → 135
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:191 → 246
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region
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