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    CG4025 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31177, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG4025provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025624
    Locus tag
    Dmel_CG4025
    See related
    AllianceGenome:FB:FBgn0025624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.169; Dmel\CG4025; DRAM; EG:22E5.9
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in acute myocardial infarction and cone-rod dystrophy 21. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4025 in Genome Data Viewer
    Location:
    2C10-2C10; 1-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2076966..2078455)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1970999..1972488)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44382 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 76 Neighboring gene corkscrew

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. O'Prey J, et al. Cell Cycle, 2009 Jul 15. PMID 19556885
    2. Genetic dissection of the phosphoinositide cycle in Drosophila photoreceptors. Liu CH, et al. J Cell Sci, 2018 Apr 19. PMID 29567856, Free PMC Article
    3. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
    4. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
    5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4025-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2076966..2078455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130623.3 → NP_569979.1  uncharacterized protein Dmel_CG4025 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77262
      Related
      FBpp0070359
      Conserved Domains (1) summary
      pfam10277
      Location:5 → 229
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77262 O77262

    Gene LinkOut

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