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    Tpr2 Tetratricopeptide repeat protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34984, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpr2provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032586
    Locus tag
    Dmel_CG4599
    See related
    AllianceGenome:FB:FBgn0032586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD24941; CG4599; Dmel\CG4599; dtpr2; dTpr2; dTPR2; dtrpr2; EU3220; Tpr-2; tpr2; TPR2; Trp2
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in adult head. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Tpr2 in Genome Data Viewer
    Location:
    36A2-36A2; 2-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16491540..16507621)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16491540..16507621)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44994 Neighboring gene Neprilysin-like 8 Neighboring gene uncharacterized protein Neighboring gene mir-4943 stem loop Neighboring gene long non-coding RNA:CR45354

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heat shock protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 2
    Names
    CG4599-PA
    CG4599-PB
    CG4599-PC
    CG4599-PD
    CG4599-PE
    Tpr2-PA
    Tpr2-PB
    Tpr2-PC
    Tpr2-PD
    Tpr2-PE

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16491540..16507621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273572.1NP_001260501.1  tetratricopeptide repeat protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q9V3W1
      Conserved Domains (5) summary
      COG0484
      Location:401503
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:310344
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:402469
      DnaJ; DnaJ domain
      pfam00515
      Location:231264
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49114
      TPR_11; TPR repeat
    2. NM_001273573.1NP_001260502.1  tetratricopeptide repeat protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q8IP18
      Conserved Domains (5) summary
      COG0484
      Location:357459
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:266300
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:358425
      DnaJ; DnaJ domain
      pfam00515
      Location:187220
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:570
      TPR_11; TPR repeat
    3. NM_078860.3NP_523584.1  tetratricopeptide repeat protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q9V3W1
      Related
      FBpp0080423
      Conserved Domains (5) summary
      COG0484
      Location:401503
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:310344
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:402469
      DnaJ; DnaJ domain
      pfam00515
      Location:231264
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:49114
      TPR_11; TPR repeat
    4. NM_165164.2NP_723974.1  tetratricopeptide repeat protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGL2, Q8IP18
      Related
      FBpp0080424
      Conserved Domains (5) summary
      COG0484
      Location:357459
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:266300
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:358425
      DnaJ; DnaJ domain
      pfam00515
      Location:187220
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:570
      TPR_11; TPR repeat
    5. NM_001273571.1NP_001260500.1  tetratricopeptide repeat protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ9, Q8IGL2
      Conserved Domains (5) summary
      COG0484
      Location:371473
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:280314
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:372439
      DnaJ; DnaJ domain
      pfam00515
      Location:201234
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:1984
      TPR_11; TPR repeat