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    Cen Centrocortin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenprovided by FlyBase
    Official Full Name
    Centrocortinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032876
    Locus tag
    Dmel_CG1962
    See related
    AllianceGenome:FB:FBgn0032876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38E.1; cen; CG1962; Dmel\CG1962
    Summary
    Involved in embryonic cleavage. Located in centrosome and cleavage furrow. Is expressed in several structures, including embryonic central brain neurons; embryonic cortex; ganglia; germline cell; and larval nervous system. Orthologous to human CDR2 (cerebellar degeneration related protein 2) and CDR2L (cerebellar degeneration related protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cen in Genome Data Viewer
    Location:
    38D5-38D5; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20678921..20681846, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20678921..20681846, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45004 Neighboring gene I-kappaB kinase epsilon Neighboring gene uncharacterized protein Neighboring gene Hormone receptor-like in 38 Neighboring gene long non-coding RNA:CR44187

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila. Bergalet J, et al. Cell Rep, 2020 Mar 10. PMID 32160541
    2. Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation. Mehta DS, et al. G3 (Bethesda), 2022 Feb 4. PMID 35100335, Free PMC Article
    3. Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows. Kao LR, et al. Curr Biol, 2009 Jun 9. PMID 19427213, Free PMC Article
    4. A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport. Safieddine A, et al. Nat Commun, 2021 Mar 1. PMID 33649340, Free PMC Article
    5. centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis. Ryder PV, et al. J Cell Biol, 2020 Dec 7. PMID 33196763, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.
      Title: centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.
    2. Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila.
      Title: Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrocortin
    Names
    CG1962-PA
    CG1962-PB
    Cen-PA
    Cen-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20678921..20681846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136205.4 → NP_610049.1  centrocortin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK6
      Related
      FBpp0080929
      Conserved Domains (1) summary
      TIGR02168
      Location:13 → 255
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_165338.3 → NP_724279.1  centrocortin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK6
      Related
      FBpp0080931
      Conserved Domains (1) summary
      TIGR02168
      Location:13 → 255
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIK6 Q9VIK6

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