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    zetaCOP Coat Protein (coatomer) zeta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39862, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zetaCOPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) zetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040512
    Locus tag
    Dmel_CG3948
    See related
    AllianceGenome:FB:FBgn0040512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3948; copz1; CT13124; Dmel\CG3948; zeta-Cop; zeta-COP; zetaCop
    Summary
    Involved in regulation of lipid storage. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including embryonic epidermis; embryonic proventriculus; embryonic/larval salivary gland; presumptive embryonic salivary gland; and salivary gland body primordium. Orthologous to several human genes including COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zetaCOP in Genome Data Viewer
    Location:
    73B5-73B6; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16671664..16673555, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16664764..16666655, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46033 Neighboring gene G protein alpha subunit f Neighboring gene long non-coding RNA:CR45241 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lasp Neighboring gene long non-coding RNA:CR45179

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Barbosa S, et al. Traffic, 2013 Apr. PMID 23279168, Free PMC Article
    2. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Martin M, et al. Mol Biol Cell, 2005 Sep. PMID 15975902, Free PMC Article
    3. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
    4. Golgi-dependent reactivation and regeneration of Drosophila quiescent neural stem cells. Gujar MR, et al. Dev Cell, 2023 Oct 9. PMID 37567172
    5. Expression of COPI components during development of Drosophila melanogaster. Grieder NC, et al. Gene Expr Patterns, 2005 Dec. PMID 16169286

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coat protein (coatomer) zeta
    Names
    CG3948-PA
    CG3948-PB
    CG3948-PC
    COPI zeta subunit
    zetaCOP-PA
    zetaCOP-PB
    zetaCOP-PC
    zetacop

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16671664..16673555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168679.2 → NP_730188.1  coat protein (coatomer) zeta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUJ2, Q8IQP2
      Related
      FBpp0075110
      Conserved Domains (1) summary
      cl02092
      Location:1 → 138
      Clat_adaptor_s; Clathrin adaptor complex small chain

    2. NM_140653.3 → NP_648910.1  coat protein (coatomer) zeta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUJ2, Q9NKX6, Q9VV89
      Related
      FBpp0075111
      Conserved Domains (1) summary
      cd14829
      Location:10 → 142
      Zeta-COP; zeta subunit of the F-COPI complex

    3. NM_168680.2 → NP_730189.1  coat protein (coatomer) zeta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUJ2, Q8IQP1
      Related
      FBpp0075112
      Conserved Domains (1) summary
      cl02092
      Location:9 → 149
      Clat_adaptor_s; Clathrin adaptor complex small chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQP1 Q8IQP1
    Q8IQP2 Q8IQP2
    Q9VV89 Q9VV89

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