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    Taf11 TBP-associated factor 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf11provided by FlyBase
    Official Full Name
    TBP-associated factor 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0011291
    Locus tag
    Dmel_CG4079
    See related
    AllianceGenome:FB:FBgn0011291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4079; d30beta; Dmel\CG4079; dTAFII30; dTAFII30 beta; dTAFII30beta; dTAF[[II]]30; dTAF[[II]]30beta; G3; TAF; TAF1; taf11; TAF11; TAF30b; Taf30beta; TAF30beta; TAF[II]30beta; TAF[[II]]; Taf[[II]]30beta; TAF[[II]]30beta; TFIID; TFIID 28 beta; TFIID-p28beta
    Summary
    Contributes to RNA polymerase II general transcription initiation factor activity. Involved in RNAi-mediated antiviral immune response and protein-RNA complex assembly. Located in cytoplasm and nucleus. Part of transcription factor TFIID complex. Orthologous to several human genes including TAF11 (TATA-box binding protein associated factor 11); TAF11L10 (TATA-box binding protein associated factor 11 like 10); and TAF11L11 (TATA-box binding protein associated factor 11 like 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Taf11 in Genome Data Viewer
    Location:
    30C7-30C7; 2-36 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9762424..9763262, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9762424..9763262, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4e3 Neighboring gene zinc finger protein 30C Neighboring gene uninitiated Neighboring gene pickpocket 18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription. Pennington KL, et al. Proc Natl Acad Sci U S A, 2013 May 7. PMID 23610421, Free PMC Article
    2. A methionine aminopeptidase and putative regulator of translation initiation is required for cell growth and patterning in Drosophila. Cutforth T, et al. Mech Dev, 1999 Apr. PMID 10354468
    3. c-Jun binds the N terminus of human TAF(II)250 to derepress RNA polymerase II transcription in vitro. Lively TN, et al. J Biol Chem, 2001 Jul 6. PMID 11316804
    4. The role of activators in assembly of RNA polymerase II transcription complexes. Hori R, et al. Curr Opin Genet Dev, 1994 Apr. PMID 8032201
    5. Sp3 represses gene expression via the titration of promoter-specific transcription factors. Kennett SB, et al. J Biol Chem, 2002 Mar 22. PMID 11773047

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNAi-mediated antiviral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-RNA complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBP-associated factor 11
    Names
    CG4079-PA
    TBP-associated factor
    TBP-associated factor 30kD subunit beta
    Taf11-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9762424..9763262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164871.3 → NP_723484.1  TBP-associated factor 11 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49906, Q9VL90
      UniProtKB/TrEMBL
      G7H801
      Related
      FBpp0079514
      Conserved Domains (1) summary
      pfam04719
      Location:91 → 175
      TAFII28; hTAFII28-like protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49906.1 P49906

    Gene LinkOut

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