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    Fatp1 Fatty acid transport protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fatp1provided by FlyBase
    Official Full Name
    Fatty acid transport protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0267828
    Locus tag
    Dmel_CG46149
    See related
    AllianceGenome:FB:FBgn0267828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0121795.74; CG45083; CG46149; CG7400; dFatp; dFATP; Dmel\CG46149; Dromel_CG7400_FBtr0080133_fatp_mORF; Dromel_CG7400_FBtr0080133_fatp_uORF; fatp; Fatp; FATP; l(2)k10307; SLC27A1/4; SLC27A4
    Old locus tag
    Dmel_CG45083; Dmel_CG7400
    Summary
    Predicted to enable long-chain fatty acid transmembrane transporter activity and long-chain fatty acid-CoA ligase activity. Involved in triglyceride homeostasis. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; adult optic lobe; gut section; and pigment cell. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fatp1 in Genome Data Viewer
    Location:
    31F4-31F5; 2-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10510672..10517218, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Myosin 31DF Neighboring gene antisense RNA:CR44224 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat 47 Neighboring gene Lipase 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033779.5 Chromosome 2L Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dFatp regulates nutrient distribution and long-term physiology in Drosophila. Sujkowski A, et al. Aging Cell, 2012 Dec. PMID 22809097, Free PMC Article
    2. Fatty acid transport proteins in disease: New insights from invertebrate models. Dourlen P, et al. Prog Lipid Res, 2015 Oct. PMID 26416577
    3. The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells. Dourlen P, et al. J Vis Exp, 2013 Sep 20. PMID 24084155, Free PMC Article
    4. Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival. Dourlen P, et al. PLoS Genet, 2012. PMID 22844251, Free PMC Article
    5. The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Shi W, et al. Genetics, 2003 Dec. PMID 14704172, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid transport protein 1
    Names
    CG46149-PA
    CG46149-PB
    CG46149-PE
    CG46149-PF
    Fatp1-PA
    Fatp1-PB
    Fatp1-PE
    Fatp1-PF
    fatty acid (long chain) transport protein
    fatty acid transport protein
    NP_001162940.3
    NP_001260354.1
    NP_524723.2
    NP_723597.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10510672..10517218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164934.2 → NP_723597.1  fatty acid transport protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E1, Q9VKU1
      Conserved Domains (2) summary
      cd05939
      Location:79 → 592
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:33 → 626
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    2. NM_079984.4 → NP_524723.2  fatty acid transport protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E1, Q9VKU1
      Conserved Domains (2) summary
      cd05939
      Location:79 → 592
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:33 → 626
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    3. NM_001169469.3 → NP_001162940.3  fatty acid transport protein 1, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHE4
      Conserved Domains (2) summary
      cd05939
      Location:199 → 712
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:153 → 746
      PRK08279; long-chain-acyl-CoA synthetase; Validated

    4. NM_001273425.3 → NP_001260354.1  fatty acid transport protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E1, Q9VKU1
      Conserved Domains (2) summary
      cd05939
      Location:79 → 592
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
      PRK08279
      Location:33 → 626
      PRK08279; long-chain-acyl-CoA synthetase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHE4 E1JHE4
    Q9VKU1 Q9VKU1

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