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    HDAC4 Histone deacetylase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32278, updated on 17-Dec-2024

    Summary

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    Official Symbol
    HDAC4provided by FlyBase
    Official Full Name
    Histone deacetylase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0041210
    Locus tag
    Dmel_CG1770
    See related
    AllianceGenome:FB:FBgn0041210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1770; dHDAC4; DHDAC4; Dmel\CG1770; dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a
    Summary
    Enables histone deacetylase activity. Involved in several processes, including insulin receptor signaling pathway; long-term memory; and positive regulation of DNA-templated transcription. Located in cytosol and nucleus. Is expressed in several structures, including Kenyon cell; adult brain cell body rind; adult mushroom body; calyx of adult mushroom body; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in ataxia telangiectasia; eating disorder; and retinal degeneration. Orthologous to several human genes including HDAC4 (histone deacetylase 4); HDAC5 (histone deacetylase 5); and HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HDAC4 in Genome Data Viewer
    Location:
    11E8-11E9; 1-42 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13262687..13285632, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13156720..13179665, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene multiple edematous wings Neighboring gene uncharacterized protein Neighboring gene comatose Neighboring gene uncharacterized protein Neighboring gene Remoulade

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased intron retention is a post-transcriptional signature associated with progressive aging and Alzheimer's disease. Adusumalli S, et al. Aging Cell, 2019 Jun. PMID 30868713, Free PMC Article
    2. Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila. Schwartz S, et al. Mol Brain, 2023 May 16. PMID 37194019, Free PMC Article
    3. Increased Abundance of Nuclear HDAC4 Impairs Neuronal Development and Long-Term Memory. Main P, et al. Front Mol Neurosci, 2021. PMID 33859551, Free PMC Article
    4. Class IIa histone deacetylases are conserved regulators of circadian function. Fogg PC, et al. J Biol Chem, 2014 Dec 5. PMID 25271152, Free PMC Article
    5. The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart? Fitzsimons HL. Neurobiol Learn Mem, 2015 Sep. PMID 26074448

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis.
      Title: Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis.
    2. SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K(+) and water transport molecules
      Title: SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water.
    3. SIK3-HDAC4 signaling in M cells regulates MSDR by regulating the molecular oscillation in DN1 neurons.
      Title: SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons.
    4. We also demonstrate that HDAC4 and Ubc9 interact genetically during memory formation, opening new avenues for investigating the mechanisms through which HDAC4 regulates memory formation and other neurological processes.
      Title: Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9.
    5. RNAi-mediated knockdown of HDAC4 in Drosophila dampens circadian function.
      Title: Class IIa histone deacetylases are conserved regulators of circadian function.
    6. HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation
      Title: The histone deacetylase HDAC4 regulates long-term memory in Drosophila.
    7. dHDAC4, is a novel, catalytically active class II Drosophila histone deacetylase and is involved in the segmentation regulatory pathway and suggested complex transcriptional regulation as a potential mechanism that controls its expression
      Title: Histone deacetylase dHDAC4 is involved in segmentation of the Drosophila embryo and is regulated by gap and pair-rule genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone deacetylase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase 4
    Names
    CG1770-PB
    CG1770-PD
    CG1770-PE
    CG1770-PF
    CG1770-PG
    CG1770-PH
    CG1770-PI
    CG1770-PJ
    HDAC4-PB
    HDAC4-PD
    HDAC4-PE
    HDAC4-PF
    HDAC4-PG
    HDAC4-PH
    HDAC4-PI
    HDAC4-PJ
    NP_001014736.2
    NP_001245651.1
    NP_001259507.1
    NP_001259508.1
    NP_001259509.1
    NP_001259510.1
    NP_572868.3
    NP_727682.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13262687..13285632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272578.2 → NP_001259507.1  histone deacetylase 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHQ2, Q8I9J6
      Conserved Domains (2) summary
      cd11681
      Location:837 → 1211
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:43 → 87
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001272581.2 → NP_001259510.1  histone deacetylase 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259510.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7X6C7, M9PJM2
      Conserved Domains (2) summary
      cd11681
      Location:773 → 1147
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:3 → 50
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_132640.6 → NP_572868.3  histone deacetylase 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572868.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I9J6, Q9VYF3
      Conserved Domains (2) summary
      cd11681
      Location:820 → 1194
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:43 → 97
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    4. NM_001272580.2 → NP_001259509.1  histone deacetylase 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7X6C7, M9PJM2
      Conserved Domains (2) summary
      cd11681
      Location:773 → 1147
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:3 → 50
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    5. NM_001272579.2 → NP_001259508.1  histone deacetylase 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7X6C7, Q8IR69
      Conserved Domains (1) summary
      cd11681
      Location:749 → 1123
      HDAC_classIIa; Histone deacetylases, class IIa

    6. NM_001014736.5 → NP_001014736.2  histone deacetylase 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014736.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E49, Q8I9J7
      Conserved Domains (2) summary
      cd11681
      Location:771 → 1145
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:43 → 97
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    7. NM_001258722.3 → NP_001245651.1  histone deacetylase 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEF2, Q8I9J6
      Conserved Domains (2) summary
      cd11681
      Location:810 → 1184
      HDAC_classIIa; Histone deacetylases, class IIa
      cl23765
      Location:43 → 86
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    8. NM_167356.3 → NP_727682.1  histone deacetylase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7X6C7, Q8IR69
      Related
      FBpp0073629
      Conserved Domains (1) summary
      cd11681
      Location:749 → 1123
      HDAC_classIIa; Histone deacetylases, class IIa
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEF2 M9NEF2
    M9PHQ2 M9PHQ2
    M9PJM2 M9PJM2
    Q59E49 Q59E49
    Q8I9J6 Q8I9J6
    Q8I9J7 Q8I9J7
    Q8IR69 Q8IR69
    Q9VYF3 Q9VYF3

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