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    Edc3 Enhancer of decapping 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Edc3provided by FlyBase
    Official Full Name
    Enhancer of decapping 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036735
    Locus tag
    Dmel_CG6311
    See related
    AllianceGenome:FB:FBgn0036735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6311; DmEDC3; Dmel\CG6311; EDC3; Lsm16; LSm16; LSM16
    Summary
    Predicted to enable mRNA binding activity. Involved in mRNA catabolic process. Located in P-body. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 50. Orthologous to human EDC3 (enhancer of mRNA decapping 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Edc3 in Genome Data Viewer
    Location:
    74D2-74D2; 3-45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17525333..17529861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17518433..17522961, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene U4-U6 small nuclear riboprotein factor 60K Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR45165 Neighboring gene Nedd4 Neighboring gene Jonah 74E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Tritschler F, et al. Mol Cell, 2009 Mar 13. PMID 19285948
    2. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Jinek M, et al. RNA, 2008 Oct. PMID 18755833, Free PMC Article
    3. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. Fromm SA, et al. EMBO J, 2012 Jan 18. PMID 22085934, Free PMC Article
    4. A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Tritschler F, et al. Mol Cell Biol, 2007 Dec. PMID 17923697, Free PMC Article
    5. ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition. Wang M, et al. Elife, 2017 Sep 6. PMID 28875934, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tral and EDC3 specifically interact with the decapping activator DCP1 and the DEAD-box helicase Me31B, in Drosophila cells.
      Title: Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes.
    2. The modular architecture enables enhancer of decapping 3 (EDC3) to interact with multiple components of the decapping machinery, including DCP1, DCP2, and Me31B.
      Title: A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of decapping 3
    Names
    CG6311-PB
    Edc3-PB
    enhancer of decapping-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17525333..17529861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140735.3 → NP_648992.1  enhancer of decapping 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T042, Q95SZ2, Q9VVI2
      UniProtKB/TrEMBL
      C6TP77
      Related
      FBpp0074970
      Conserved Domains (3) summary
      cd01737
      Location:5 → 69
      LSm16_N; Like-Sm protein 16, N-terminal domain
      pfam09532
      Location:343 → 397
      FDF; FDF domain
      cl00318
      Location:453 → 583
      YjeF_N; YjeF-related protein N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVI2.1 Q9VVI2

    Gene LinkOut

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