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    by blistery [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    byprovided by FlyBase
    Official Full Name
    blisteryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000244
    Locus tag
    Dmel_CG9379
    See related
    AllianceGenome:FB:FBgn0000244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3R-B; BcDNA:RE65113; CG9379; CT26639; Dmel\CG9379; tensin
    Summary
    Enables actin filament binding activity; cytoskeletal protein-membrane anchor activity; and phosphotyrosine residue binding activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces and positive regulation of cell-cell adhesion mediated by integrin. Located in focal adhesion. Is expressed in several structures, including adult heart; foregut primordium; gut section; keyhole structure; and organism subdivision. Orthologous to several human genes including TNS1 (tensin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    85D19-85D22; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9528238..9533011, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5353960..5358733, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rlb1 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene uncharacterized protein Neighboring gene mir-2283 stem loop Neighboring gene Lysine demethylase 3 Neighboring gene murashka Neighboring gene long non-coding RNA:CR42549 Neighboring gene RNA-binding protein S1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila tensin plays an essential role in cell migration and planar polarity formation during oogenesis by mediating integrin-dependent extracellular signals to actin organization. Cha IJ, et al. Biochem Biophys Res Commun, 2017 Mar 11. PMID 28161642
    2. Drosophila as Model System to Study Ras-Mediated Oncogenesis: The Case of the Tensin Family of Proteins. Martínez-Abarca Millán A, et al. Genes (Basel), 2023 Jul 23. PMID 37510408, Free PMC Article
    3. Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene. Kemphues KJ, et al. Cell, 1980 Sep. PMID 6773669
    4. Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arrays. Fuller MT, et al. J Cell Biol, 1988 Jul. PMID 3134362, Free PMC Article
    5. Mechanical force regulates integrin turnover in Drosophila in vivo. Pines M, et al. Nat Cell Biol, 2012 Sep. PMID 22885771

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal protein-membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    blistery
    Names
    3R-B
    CG9379-PA
    CG9379-PC
    CG9379-PD
    by-PA
    by-PC
    by-PD
    tensin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9528238..9533011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141644.4 → NP_649901.1  blistery, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP54, Q9VHC3
      Related
      FBpp0081597
      Conserved Domains (2) summary
      cd09927
      Location:454 → 559
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:578 → 711
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    2. NM_001170099.3 → NP_001163570.1  blistery, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP54, Q9VHC3
      Conserved Domains (2) summary
      cd09927
      Location:454 → 559
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:578 → 711
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    3. NM_001170098.2 → NP_001163569.1  blistery, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP54, Q9VHC3
      Conserved Domains (2) summary
      cd09927
      Location:454 → 559
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:578 → 711
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYE7 Q8SYE7
    Q9VHC3 Q9VHC3

    Gene LinkOut

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