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    prage prage [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prageprovided by FlyBase
    Official Full Name
    prageprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283741
    Locus tag
    Dmel_CG42666
    See related
    AllianceGenome:FB:FBgn0283741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14799; CG14800; CG14801; CG17968; CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1
    Old locus tag
    Dmel_CG14799; Dmel_CG14801
    Summary
    Predicted to enable exonuclease activity. Involved in egg activation. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; epithelium; and gut section. Orthologous to human REXO1L1P (REXO1 like 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prage in Genome Data Viewer
    Location:
    2B9-2B12; 1-0.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1773719..1853667)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1667752..1747700)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sarcoglycan delta Neighboring gene Adenosine deaminase acting on RNA Neighboring gene mir-981 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) delta Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease. Cui J, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172196, Free PMC Article
    2. Phospho-regulation pathways during egg activation in Drosophila melanogaster. Krauchunas AR, et al. Genetics, 2013 Sep. PMID 23792954, Free PMC Article
    3. Modulation of MAPK activities during egg activation in Drosophila. Sackton KL, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820472
    4. Genes Containing Long Introns Occupy Series of Bands and Interbands In Drosophila melanogaster polytene Chromosomes. Khoroshko VA, et al. Genes (Basel), 2020 Apr 11. PMID 32290448, Free PMC Article
    5. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 1820632-1820953 mobile_element_type = transposon:INE-1{}5466
    • Loc: 1827211-1827252 mobile_element_type = transposon:INE-1{}5468

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prage
    Names
    CG42666-PA
    CG42666-PB
    CG42666-PC
    CG42666-PD
    CG42666-PE
    CG42666-PF
    CG42666-PG
    CG42666-PH
    CG42666-PI
    CG42666-PJ
    CG42666-PK
    prage-PA
    prage-PB
    prage-PC
    prage-PD
    prage-PE
    prage-PF
    prage-PG
    prage-PH
    prage-PI
    prage-PJ
    prage-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1773719..1853667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258549.1 → NP_001245478.1  prage, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRW9, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:576 → 727
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:565 → 727
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:504 → 540
      PH-like; Pleckstrin homology-like domain

    2. NM_001258551.1 → NP_001245480.1  prage, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245480.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRW9, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:576 → 727
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:565 → 727
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:504 → 540
      PH-like; Pleckstrin homology-like domain

    3. NM_001258552.1 → NP_001245481.1  prage, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE5, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:686 → 837
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:675 → 837
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:614 → 650
      PH-like; Pleckstrin homology-like domain

    4. NM_001201599.2 → NP_001188528.1  prage, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE5, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:686 → 837
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:675 → 837
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:614 → 650
      PH-like; Pleckstrin homology-like domain

    5. NM_001258550.1 → NP_001245479.1  prage, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRW9, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:576 → 727
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:565 → 727
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:504 → 540
      PH-like; Pleckstrin homology-like domain

    6. NM_130589.3 → NP_569945.1  prage, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T023, Q960E5
      Related
      FBpp0291794
      Conserved Domains (3) summary
      cd06145
      Location:621 → 772
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:610 → 772
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:549 → 585
      PH-like; Pleckstrin homology-like domain

    7. NM_166908.2 → NP_726769.1  prage, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRW9, Q960E5
      Related
      FBpp0291795
      Conserved Domains (3) summary
      cd06145
      Location:576 → 727
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:565 → 727
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:504 → 540
      PH-like; Pleckstrin homology-like domain

    8. NM_001272214.1 → NP_001259143.1  prage, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRW9, Q960E5
      Conserved Domains (3) summary
      cd06145
      Location:576 → 727
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:565 → 727
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:504 → 540
      PH-like; Pleckstrin homology-like domain

    9. NM_001201600.2 → NP_001188529.1  prage, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E5, Q9W557
      Conserved Domains (3) summary
      cd06145
      Location:595 → 746
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:584 → 746
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:523 → 559
      PH-like; Pleckstrin homology-like domain

    10. NM_166907.2 → NP_726768.1  prage, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E5, Q9W557
      Related
      FBpp0291796
      Conserved Domains (3) summary
      cd06145
      Location:595 → 746
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:584 → 746
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:523 → 559
      PH-like; Pleckstrin homology-like domain

    11. NM_166906.2 → NP_726767.1  prage, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960E5, Q9W557
      Related
      FBpp0291797
      Conserved Domains (3) summary
      cd06145
      Location:595 → 746
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      COG0847
      Location:584 → 746
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl17171
      Location:523 → 559
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C7LAE5 C7LAE5
    O76875 O76875
    Q8IRW9 Q8IRW9
    Q8T023 Q8T023
    Q960E5 Q960E5
    Q9W557 Q9W557
    Q9W558 Q9W558

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