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    CG3638 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31071, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG3638provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261444
    Locus tag
    Dmel_CG3638
    See related
    AllianceGenome:FB:FBgn0261444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG00376; Dmel\CG3638; EG:33C11.3; TTYH2
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Located in plasma membrane. Is expressed in adult head. Orthologous to human TTYH1 (tweety family member 1); TTYH2 (tweety family member 2); and TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3638 in Genome Data Viewer
    Location:
    1E4-1E5; 1-0.1 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1215289..1236684, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1109322..1130717, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Activating transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. Suzuki M. Exp Physiol, 2006 Jan. PMID 16219661
    2. A microRNA that controls the emergence of embryonic movement. Menzies JAC, et al. Elife, 2024 Jun 13. PMID 38869942, Free PMC Article
    3. Glial TGFβ activity promotes neuron survival in peripheral nerves. Lassetter AP, et al. J Cell Biol, 2023 Jan 2. PMID 36399182, Free PMC Article
    4. The exon junction complex differentially marks spliced junctions. Saulière J, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818392
    5. Mutations in many genes affect aggressive behavior in Drosophila melanogaster. Edwards AC, et al. BMC Biol, 2009 Jun 11. PMID 19519879, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables volume-sensitive chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    BG00376
    CG3638-PB
    CG3638-PF
    CG3638-PG
    CG3638-PH
    CG3638-PI
    CG3638-PJ
    CG3638-PK
    CG3638-PL
    tweety-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1215289..1236684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166874.3 → NP_726722.1  uncharacterized protein Dmel_CG3638, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WHI0, O97175, Q8IRY1, Q8IRY2, Q8IRY3, Q9U1L5, Q9W5A5
      Related
      FBpp0307920
      Conserved Domains (1) summary
      cl12141
      Location:36 → 448
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    2. NM_166873.3 → NP_726721.1  uncharacterized protein Dmel_CG3638, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726721.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEN6
      Related
      FBpp0070239
      Conserved Domains (1) summary
      pfam04906
      Location:21 → 432
      Tweety; Tweety

    3. NM_130541.4 → NP_569897.4  uncharacterized protein Dmel_CG3638, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569897.4

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam04906
      Location:21 → 432
      Tweety; Tweety

    4. NM_001316632.1 → NP_001303561.1  uncharacterized protein Dmel_CG3638, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0X0Z7
      Conserved Domains (1) summary
      cd07912
      Location:1 → 421
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    5. NM_001272195.1 → NP_001259124.1  uncharacterized protein Dmel_CG3638, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGE0
      Conserved Domains (1) summary
      cd07912
      Location:1 → 421
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    6. NM_001258531.2 → NP_001245460.1  uncharacterized protein Dmel_CG3638, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEN6
      Conserved Domains (1) summary
      pfam04906
      Location:21 → 432
      Tweety; Tweety

    7. NM_166872.3 → NP_726720.3  uncharacterized protein Dmel_CG3638, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726720.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W5A5
      Conserved Domains (1) summary
      cd07912
      Location:1 → 421
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    8. NM_001316631.1 → NP_001303560.1  uncharacterized protein Dmel_CG3638, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0X7W8
      Conserved Domains (1) summary
      pfam04906
      Location:21 → 432
      Tweety; Tweety
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0X0Z7 A0A0S0X0Z7
    A0A0S0X7W8 A0A0S0X7W8
    M9NEN6 M9NEN6
    M9PGE0 M9PGE0
    Q8MRZ6 Q8MRZ6
    Q9W5A5.2 Q9W5A5

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