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    His1:CG31617 histone H1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    His1:CG31617provided by FlyBase
    Official Full Name
    histone H1provided by FlyBase
    Primary source
    FLYBASE:FBgn0051617
    Locus tag
    Dmel_CG31617
    See related
    AllianceGenome:FB:FBgn0051617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31617; Dmel\CG31617; his1
    Summary
    Predicted to enable chromatin DNA binding activity. Involved in chromosome organization and heterochromatin formation. Predicted to be located in chromatin. Predicted to be part of nucleosome. Is expressed in adult heart. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See His1:CG31617 in Genome Data Viewer
    Location:
    39D3-39D3; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21421855..21422877)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21421855..21422877)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H4 Neighboring gene histone H3 Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin. Bayona-Feliu A, et al. Nat Commun, 2017 Aug 18. PMID 28819201, Free PMC Article
    2. Hinfp is a guardian of the somatic genome by repressing transposable elements. Nirala NK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34620709, Free PMC Article
    3. Microarray analysis of replicate populations selected against a wing-shape correlation in Drosophila melanogaster. Weber KE, et al. Genetics, 2008 Feb. PMID 18245369, Free PMC Article
    4. Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity. Vujatovic O, et al. Nucleic Acids Res, 2012 Jul. PMID 22406835, Free PMC Article
    5. Chromatin state transitions in the Drosophila intestinal lineage identify principles of cell-type specification. Josserand M, et al. Dev Cell, 2023 Dec 18. PMID 38056452

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the linker histone H1 prevents DNA:RNA hybrids accumulation and genome instability in heterochromatin.
      Title: Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone H1
    Names
    CG31617-PA
    His1:CG31617-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21421855..21422877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165380.4 → NP_724341.1  histone H1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02255, Q4ABD3
      UniProtKB/TrEMBL
      C4IY08
      Related
      FBpp0085248
      Conserved Domains (1) summary
      pfam00538
      Location:46 → 118
      Linker_histone; linker histone H1 and H5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02255.1 P02255

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials