pyd polychaetoid [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pydprovided by FlyBase
Official Full Name: polychaetoidprovided by FlyBase
Primary source: FLYBASE:FBgn0262614
Locus tag: Dmel_CG43140
See related: AllianceGenome:FB:FBgn0262614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11782; CG11962; CG12409; CG31349; CG43140; CG9729; CG9731; CG9763; CT36877; Dmel\CG43140; dzo-1; DZO-1; Pch; Pyd; pyd(Z01); Pyd/ZO-1; tam; Tamou; xvt; ZO-1; ZO1
Old locus tag: Dmel_CG31349; Dmel_CG9731
Summary: Enables cell adhesion molecule binding activity. Involved in several processes, including R8 cell development; embryonic development via the syncytial blastoderm; and open tracheal system development. Located in several cellular components, including adherens junction; basolateral plasma membrane; and nephrocyte diaphragm. Is expressed in several structures, including adult head; adult heart; epithelium; gut section; and nephrocyte. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to several human genes including TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85B2-85B7; 3-48 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8827068..8931896, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4652790..4757618, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
Title: Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
Title: The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
Here, we show that a specific isoform of Polychaetoid/ZO-1, Pyd-P, is essential for Drosophila SDs, since, in pyd mutants devoid of Pyd-P, SDs do not form and the SD component Dumbfounded accumulates at ectopic septate-like junctions between abnormally aggregated nephrocytes
Title: A specific isoform of Pyd/ZO-1 mediates junctional remodeling and formation of slit diaphragms.
Canoe and Polychaetoid stabilize Bazooka/Par3 at cell-cell junctions, helping maintain balanced apical contractility and tissue integrity.
Title: The Drosophila Afadin and ZO-1 homologues Canoe and Polychaetoid act in parallel to maintain epithelial integrity when challenged by adherens junction remodeling.
Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.
Title: Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.
Most embryos lacking Pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system
Title: The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled.
A core antagonistic interaction between Pyd and the WW domain E3 ubiquitin ligase Su(dx), was identified.
Title: Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue.
Results suggest that polychaetoid modulates adherens junction strength and Roughest-mediated preferential cell adhesion.
Title: Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c8896023-8894928 mobile_element_type = transposon:1360{}1270

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branch fusion, open tracheal system	HMP more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephrocyte diaphragm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in nephrocyte diaphragm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polychaetoid

Names: CG43140-PA; CG43140-PB; CG43140-PC; CG43140-PF; CG43140-PG; CG43140-PI; CG43140-PJ; CG43140-PK; CG43140-PL; CG43140-PM; CG43140-PO; CG43140-PP; extra verticals; failed fusions; pyd-PA; pyd-PB; pyd-PC; pyd-PF; pyd-PG; pyd-PI; pyd-PJ; pyd-PK; pyd-PL; pyd-PM; pyd-PO; pyd-PP; tamou

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8827068..8931896 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260069.2 → NP_001246998.1 polychaetoid, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246998.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6Y7

Conserved Domains (4) summary

cd11859
Location:729 → 790

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:831 → 1007

GuKc; Guanylate kinase homologues

cd00992
Location:249 → 334

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:2263 → 2351

ZU5; ZU5 domain
NM_057349.7 → NP_476697.3 polychaetoid, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476697.3

Status: REVIEWED

UniProtKB/TrEMBL

Q94880, Q9VHK4

Related

FBpp0293838

Conserved Domains (3) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_170646.6 → NP_731293.3 polychaetoid, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731293.3

Status: REVIEWED

UniProtKB/TrEMBL

Q960N4, Q9VHK1

Conserved Domains (3) summary

cd11859
Location:866 → 927

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:968 → 1144

GuKc; Guanylate kinase homologues

cd00992
Location:386 → 471

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001144556.2 → NP_001138028.1 polychaetoid, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138028.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0U1, Q94880

Conserved Domains (3) summary

cd11859
Location:517 → 578

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:619 → 795

GuKc; Guanylate kinase homologues

cd00992
Location:37 → 122

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_169246.3 → NP_731292.2 polychaetoid, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731292.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8INQ0, Q94880

Related

FBpp0293839

Conserved Domains (3) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_169245.3 → NP_731291.2 polychaetoid, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731291.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHK3

Related

FBpp0293840

Conserved Domains (4) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00791
Location:1958 → 2046

ZU5; ZU5 domain
NM_001104241.2 → NP_001097711.1 polychaetoid, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097711.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JQV7, Q94880

Conserved Domains (3) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001260072.2 → NP_001247001.1 polychaetoid, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247001.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JQV7, Q94880

Conserved Domains (3) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_176426.4 → NP_788603.1 polychaetoid, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788603.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INQ1, Q8MQQ3, Q94880

Related

FBpp0293837

Conserved Domains (3) summary

cd11859
Location:502 → 563

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:604 → 780

GuKc; Guanylate kinase homologues

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001260071.2 → NP_001247000.1 polychaetoid, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247000.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6C7, G4LU41

Conserved Domains (3) summary

cd11859
Location:624 → 685

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:726 → 902

GuKc; Guanylate kinase homologues

cd00992
Location:144 → 229

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001104242.3 → NP_001097712.1 polychaetoid, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097712.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JQV8

Conserved Domains (3) summary

cd11859
Location:785 → 846

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:887 → 1063

GuKc; Guanylate kinase homologues

cd00992
Location:305 → 390

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001382097.1 → NP_001368959.1 polychaetoid, isoform P [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6F7U5U6, G4LU41

Conserved Domains (3) summary

cd11859
Location:729 → 790

SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins

smart00072
Location:831 → 1007

GuKc; Guanylate kinase homologues

cd00992
Location:249 → 334

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K6C7		A0A0B4K6C7
A0A0B4K6Y7		A0A0B4K6Y7
A0A6F7U5U6		A0A6F7U5U6
A8JQV7		A8JQV7
A8JQV8		A8JQV8
B7Z0U1		B7Z0U1
Q7K4E2		Q7K4E2
Q8INQ0		Q8INQ0
Q8MQQ3		Q8MQQ3
Q94880		Q94880
Q95RX8		Q95RX8
Q9VHK1		Q9VHK1
Q9VHK3		Q9VHK3
Q9VHK4		Q9VHK4